Reaction profile

The FDA adverse-event record for oral bleeding

556 FDA adverse-event reports reference oral bleeding (VeDDRA 297). See the species, breeds, and drugs most associated with it below.

556
reports citing this reaction
43.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
556
Total Reports
244
Deaths
43.9%
Death Rate

Species Most Affected

Dog 423
Cat 108
Horse 13
Cattle 9
Human 1
Ferret 1
Hedgehog 1

Breeds Most Affected

Domestic Shorthair 60
Crossbred Canine/dog 41
Retriever - Labrador 32
Shepherd Dog - German 21
Boxer (German Boxer) 19
Dog (unknown) 17
Shih Tzu 17
Retriever - Golden 16
Domestic (unspecified) 14
Chihuahua 13

Associated Drugs

Carprofen 80
Maropitant Citrate 36
Moxidectin 34
Oclacitinib Maleate 33
Milbemycin Oxime + Spinosad 32
Cefovecin 28
Fluralaner Chew Tablets 28
Bedinvetmab 24
Prednisone 20
Afoxolaner 20
Gabapentin 19
Meloxicam 18
Doxycycline 17
Trilostane 16
Pyrantel Pamoate;Sarolaner 16
Isoflurane 15
Ketamine 15
Dexamethasone 14
Buprenorphine 13
Diphenhydramine Hcl 13

Oral bleeding Reaction Insights

556 reports name Oral bleeding; 244 recorded a death outcome (43.9% of reported events, not a population-level mortality rate). VeDDRA code: 297.

By species: Dog (423 reports), Cat (108 reports), Horse (13 reports). By breed: Domestic Shorthair (60), Crossbred Canine/dog (41), Retriever - Labrador (32).

Most co-reported drugs: Carprofen (80 reports), Maropitant Citrate (36 reports), Moxidectin (34 reports), Oclacitinib Maleate (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.