Deafness NOS

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VeDDRA Code: 368

311 adverse event reports referencing this reaction

311
Total Reports
18
Deaths
580.0%
Death Rate

Species Most Affected

Dog 284
Cat 26
Rabbit 1

Breeds Most Affected

Crossbred Canine/dog 36
Terrier - Yorkshire 19
Domestic Shorthair 17
Retriever - Labrador 15
Pit Bull 11
Shepherd Dog - German 11
Maltese 11
Dog (unknown) 11
Chihuahua 10
Spitz - German Pomeranian 10

Associated Drugs

Genta/Momet/Clotrim Ear Oint 70
Orbiflox/Momet/Posaco Eardrops 47
Miconazole + Polymyxin B + Prednisolone 28
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 22
Betamethasone + Florfenicol + Terbinafine 16
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 13
Prednisone 12
Genta/Betamet/Clotrim Ear Oint 12
Trilostane 11
Oclacitinib Maleate 10
Cefovecin 10
Enrofloxacin + Silver Sulfadiazine 8
Ear Cleaner (Unknown) 8
Florfenicol, Terbinafine, Betamethasone Acetate 8
Tresaderm Dermatological Solution 7
Ear Cleaner 7
Spinosad 6
Carprofen 6
Milbemycin Oxime + Spinosad 5
Tramadol 5

Data Summary

Metric Value
Total reports referencing reaction 311
Reports with fatal outcome 18
Case-fatality rate (reported events) 580.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 368.

Deafness NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 311 adverse event reports that reference Deafness NOS as a reaction term, including 18 reports with a death outcome — a 580.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 368, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Deafness NOS appears most frequently in reports for Dog (284 reports), Cat (26 reports), Rabbit (1 reports) — with Dog dominating at 284 entries. Within those species, the breeds most often named alongside this reaction are Crossbred Canine/dog (36), Terrier - Yorkshire (19), Domestic Shorthair (17). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Deafness NOS are Genta/Momet/Clotrim Ear Oint (70 reports), Orbiflox/Momet/Posaco Eardrops (47 reports), Miconazole + Polymyxin B + Prednisolone (28 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (22 reports), with Genta/Momet/Clotrim Ear Oint appearing alongside this reaction in 70 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial