Reaction profile

The FDA adverse-event record for injection site lesion

484 FDA adverse-event reports reference injection site lesion (VeDDRA 86). See the species, breeds, and drugs most associated with it below.

484
reports citing this reaction
4.8%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
484
Total Reports
23
Deaths
4.8%
Death Rate

Species Most Affected

Dog 241
Human 111
Cat 93
Cattle 15
Horse 12
Mouse 2
Goat 2
Guinea Pig 2
Pig 1
Other 1

Breeds Most Affected

Unknown 117
Domestic Shorthair 58
Retriever - Labrador 22
Dog (unknown) 18
Domestic Longhair 15
Shepherd Dog - German 10
Crossbred Canine/dog 9
Chihuahua 9
Beagle 9
Dachshund (unspecified) 8

Associated Drugs

Carprofen 73
Enrofloxacin 50
Maropitant Citrate 46
Cefovecin 43
Praziquantel 31
Tigilanol Tiglate 28
Moxidectin 27
Eprinomectin 5% Injection 24
Meloxicam 23
Buprenorphine 21
Robenacoxib 20
Dexmedetomidine 18
Butorphanol 17
Gabapentin 17
Tulathromycin 16
Anesthetic 15
Isoflurane 15
Prednisone 15
Melarsomine Dihydrochloride 15
Ketamine 14

Injection site lesion Reaction Insights

484 reports name Injection site lesion; 23 recorded a death outcome (4.8% of reported events, not a population-level mortality rate). VeDDRA code: 86.

By species: Dog (241 reports), Human (111 reports), Cat (93 reports). By breed: Unknown (117), Domestic Shorthair (58), Retriever - Labrador (22).

Most co-reported drugs: Carprofen (73 reports), Enrofloxacin (50 reports), Maropitant Citrate (46 reports), Cefovecin (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.