Implant, Abnormal

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VeDDRA Code: 99013

318 adverse event reports referencing this reaction

318
Total Reports
2
Deaths
60.0%
Death Rate

Species Most Affected

Unknown 290
Cattle 25
Ferret 3

Breeds Most Affected

Unknown 290
Cattle (unknown) 13
Mixed (Cattle) 9
Domestic ferret (Pet ferret) 3
Holstein-Friesian also known as Holstein 2
Aberdeen Angus 1

Associated Drugs

Deslorelin Acetate 68
Deslorelin 63
Zeranol 61
Estradiol, Trenbolone Acetate 23
Trenbolone Acet/Estradiol Impl 20
Trenbolone Acetate;Estradiol Benzoate 18
Estradiol Benzoate; Trenbolone Acetate 14
Estradiol Benzoate, Progesterone 8
Progesterone;Estradiol Benzoate 8
Progesterone 6
Progesterone; Estradiol Benzoate 6
Trenbolone Acet/Estrad Sr Imp 6
Zeranol Implant 5
Estradiol, Testosterone 3
Estradiol + Trenbolone 3
Estradiol 3
Synovex One Sx-10 Applicator 2
Testosterone Propionate;Estradiol Benzoate 2
Estradiol + Progesterone 1
Testosterone; Estradiol Benzoate; Tylosin Tartrate 1

Data Summary

Metric Value
Total reports referencing reaction 318
Reports with fatal outcome 2
Case-fatality rate (reported events) 60.0%
Species observed 3
Breeds observed 6
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99013.

Implant, Abnormal Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 318 adverse event reports that reference Implant, Abnormal as a reaction term, including 2 reports with a death outcome — a 60.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99013, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Implant, Abnormal appears most frequently in reports for Unknown (290 reports), Cattle (25 reports), Ferret (3 reports) — with Unknown dominating at 290 entries. Within those species, the breeds most often named alongside this reaction are Unknown (290), Cattle (unknown) (13), Mixed (Cattle) (9). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Implant, Abnormal are Deslorelin Acetate (68 reports), Deslorelin (63 reports), Zeranol (61 reports), Estradiol, Trenbolone Acetate (23 reports), with Deslorelin Acetate appearing alongside this reaction in 68 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial