Reaction profile

The FDA adverse-event record for ruminal bloat

176 FDA adverse-event reports reference ruminal bloat (VeDDRA 320). See the species, breeds, and drugs most associated with it below.

176
reports citing this reaction
87.5%
death-coded share
Cattle
most-affected species
Monensin Sodium
most-associated drug
Verify with FDA CVM →
176
Total Reports
154
Deaths
87.5%
Death Rate

Species Most Affected

Cattle 156
Dog 14
Goat 4
Sheep 2

Breeds Most Affected

Cattle (unknown) 43
Crossbred Bovine/Cattle 29
Cattle (other) 26
Mixed (Cattle) 16
Aberdeen Angus 15
Holstein-Friesian also known as Holstein 14
Jersey 5
Hereford cattle 3
Boer 2
Beefmaster 2

Associated Drugs

Monensin Sodium 80
Ractopamine Hydrochloride 36
Tylosin Phosphate 26
Tulathromycin 14
Monensin 10
Lasalocid Sodium 9
Trenbolone; Estradiol; Tylosin Tartrate 8
Doramectin 7
Enrofloxacin 6
Tildipirosin 6
Ivermectin 5
Ceftiofur 5
Lubabegron 5
Moxidectin 4
Zilpaterol 4
Milbemycin Oxime + Spinosad 4
Florfenicol 4
Trenbolone Acet/Estrad Sr Imp 4
Trenbolone Acet/Estradiol Impl 4
Tylosin 3

Ruminal bloat Reaction Insights

176 reports name Ruminal bloat; 154 recorded a death outcome (87.5% of reported events, not a population-level mortality rate). VeDDRA code: 320.

By species: Cattle (156 reports), Dog (14 reports), Goat (4 reports). By breed: Cattle (unknown) (43), Crossbred Bovine/Cattle (29), Cattle (other) (26).

Most co-reported drugs: Monensin Sodium (80 reports), Ractopamine Hydrochloride (36 reports), Tylosin Phosphate (26 reports), Tulathromycin (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.