Reaction profile

The FDA adverse-event record for iga animal morbidity greater than expected

46 FDA adverse-event reports reference iga animal morbidity greater than expected (VeDDRA 93103). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
95.7%
death-coded share
Chicken
most-affected species
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage)
most-associated drug
Verify with FDA CVM →
46
Total Reports
44
Deaths
95.7%
Death Rate

Species Most Affected

Chicken 24
Fish 17
Pig 4
Chinchilla 1

Breeds Most Affected

Unknown 25
Atlantic Salmon (Salmo salar) 17
Pig (other) 4

Associated Drugs

Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) 17
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. 15
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal 9
Deletion Of Exon 7 Of Cd163 Gene In Domestic Pigs 4
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. Further, These Animals Are Back-Up Genetic Flock Not Used For Sebelipase Alfa Production. 1

IGA Animal morbidity greater than expected Reaction Insights

46 reports name IGA Animal morbidity greater than expected; 44 recorded a death outcome (95.7% of reported events, not a population-level mortality rate). VeDDRA code: 93103.

By species: Chicken (24 reports), Fish (17 reports), Pig (4 reports). By breed: Unknown (25), Atlantic Salmon (Salmo salar) (17), Pig (other) (4).

Most co-reported drugs: Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) (17 reports), Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. (15 reports), Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal (9 reports), Deletion Of Exon 7 Of Cd163 Gene In Domestic Pigs (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.