IGA Animal morbidity greater than expected

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VeDDRA Code: 93103

46 adverse event reports referencing this reaction

46
Total Reports
44
Deaths
9570.0%
Death Rate

Species Most Affected

Chicken 24
Fish 17
Pig 4
Chinchilla 1

Breeds Most Affected

Unknown 25
Atlantic Salmon (Salmo salar) 17
Pig (other) 4

Associated Drugs

Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) 17
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. 15
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal 9
Deletion Of Exon 7 Of Cd163 Gene In Domestic Pigs 4
Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. Further, These Animals Are Back-Up Genetic Flock Not Used For Sebelipase Alfa Production. 1

Data Summary

Metric Value
Total reports referencing reaction 46
Reports with fatal outcome 44
Case-fatality rate (reported events) 9570.0%
Species observed 4
Breeds observed 3
Drugs associated with reaction 5

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 93103.

IGA Animal morbidity greater than expected Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 46 adverse event reports that reference IGA Animal morbidity greater than expected as a reaction term, including 44 reports with a death outcome — a 9570.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 93103, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

IGA Animal morbidity greater than expected appears most frequently in reports for Chicken (24 reports), Fish (17 reports), Pig (4 reports) — with Chicken dominating at 24 entries. Within those species, the breeds most often named alongside this reaction are Unknown (25), Atlantic Salmon (Salmo salar) (17), Pig (other) (4). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with IGA Animal morbidity greater than expected are Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) (17 reports), Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal. (15 reports), Sebelipase Alfa Strength Indicated Is For Final Drug Product And Is Not Administered To The Animal (9 reports), Deletion Of Exon 7 Of Cd163 Gene In Domestic Pigs (4 reports), with Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) appearing alongside this reaction in 17 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

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Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial