Reaction profile

The FDA adverse-event record for agonal breathing

158 FDA adverse-event reports reference agonal breathing (VeDDRA 2777). See the species, breeds, and drugs most associated with it below.

158
reports citing this reaction
86.7%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
158
Total Reports
137
Deaths
86.7%
Death Rate

Species Most Affected

Dog 101
Cat 51
Horse 3
Pig 1
Goat 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 32
Retriever - Labrador 8
Dog (unknown) 5
Cat (unknown) 5
Domestic Longhair 5
Boxer (German Boxer) 4
Great Pyrenees 4
Retriever - Golden 4
Maltese 4
Chihuahua 4

Associated Drugs

Maropitant Citrate 29
Buprenorphine 19
Bedinvetmab 15
Pentobarbital Sodium + Phenytoin Sodium 12
Fluid Therapy 11
Carprofen 10
Cefovecin 8
Metoclopramide 8
Metronidazole 8
Moxidectin 7
Enrofloxacin 7
Afoxolaner 6
Trilostane 6
Isoflurane 6
Nitenpyram 6
Rabies Vaccine 6
Dextrose 6
Frunevetmab 6
Canine Parvovirus Monoclonal Antibody 6
Ondansetron 6

Agonal breathing Reaction Insights

158 reports name Agonal breathing; 137 recorded a death outcome (86.7% of reported events, not a population-level mortality rate). VeDDRA code: 2777.

By species: Dog (101 reports), Cat (51 reports), Horse (3 reports). By breed: Domestic Shorthair (32), Retriever - Labrador (8), Dog (unknown) (5).

Most co-reported drugs: Maropitant Citrate (29 reports), Buprenorphine (19 reports), Bedinvetmab (15 reports), Pentobarbital Sodium + Phenytoin Sodium (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.