Reaction profile

The FDA adverse-event record for foam in the trachea

58 FDA adverse-event reports reference foam in the trachea (VeDDRA 875). See the species, breeds, and drugs most associated with it below.

58
reports citing this reaction
87.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
58
Total Reports
51
Deaths
87.9%
Death Rate

Species Most Affected

Dog 31
Cattle 16
Cat 8
Horse 2
Sheep 1

Breeds Most Affected

Domestic Shorthair 6
Holstein-Friesian also known as Holstein 4
Aberdeen Angus 4
Boxer (German Boxer) 3
Crossbred Bovine/Cattle 3
Spitz - German Pomeranian 2
Mixed (Dog) 2
Pit Bull 2
Shepherd Dog - German 2
Beagle 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Cefovecin 4
Dexmedetomidine Hydrochloride 3
Ketamine 3
Maropitant Citrate 3
Furosemide 3
Enrofloxacin 3
Melarsomine Dihydrochloride Injection 3
Carprofen 3
Dexamethasone 3
Eprinomectin 3
Epinephrine 3
Spinosad 2
Tramadol 2
Butorphanol 2
Flunixin Meglumine Injectable 2
Clostr Perf*2/Clos Others*6 Kb 2
Buprenorphine 2
Tildipirosin Injectable 2
Afoxolaner 2

Foam in the trachea Reaction Insights

58 reports name Foam in the trachea; 51 recorded a death outcome (87.9% of reported events, not a population-level mortality rate). VeDDRA code: 875.

By species: Dog (31 reports), Cattle (16 reports), Cat (8 reports). By breed: Domestic Shorthair (6), Holstein-Friesian also known as Holstein (4), Aberdeen Angus (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (12 reports), Cefovecin (4 reports), Dexmedetomidine Hydrochloride (3 reports), Ketamine (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.