Reaction profile

The FDA adverse-event record for respiratory distress

1,259 FDA reports name respiratory distress, a high-volume reaction in the CVM extract (VeDDRA 840). Plate stamps and neighbourhood peers follow.

#326 of 2,481
by report volume (all reactions)
1,259
reports citing this reaction
59.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Respiratory distress has 1,259 reports now versus 1,242 in that prior snapshot: 17 more (1.4%).

Report change
+17
Death-coded reports
+6
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Respiratory distress changes

FDA AER · VeDDRA plate

Code 840 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,259 reports
  • DEATH-HOT 59.6%
  • UPPER-Q #326/2481
  • PHOTO-FINISH Tense abdomen
  • SPECIES-DOG Dog · 753
  • DRUG-LEAD Cefovecin · 102
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Tense abdomen (±3 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Respiratory distress

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Stomach upset · near1266Incorrect route of dr… · near1264Respiratory distress · this …1259Tense abdomen · near1256Decreased drinking · near1250Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Respiratory distress

Respiratory distress: high death-coded share in the FDA AER plate

Signature read: 750 death-coded reports is a heavy tail count for Respiratory distress in the CVM extract. Report volume is upper-third scale: 1,259 named reports in the openFDA extract. Death-coded share is upper-third: 750 of 1,259 reports (59.6% of named reports). Nearest volume peer: Tense abdomen (±3 reports). Lead species Dog (753). Lead co-reported drug Cefovecin (102).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 753
Cat 340
Cattle 94
Horse 27
Human 20
Pig 10
Ferret 3
Sheep 2
Other Birds 2
Rabbit 2

Breeds Most Affected

Domestic Shorthair 174
Retriever - Labrador 60
Crossbred Canine/dog 52
Terrier - Yorkshire 39
Chihuahua 38
Domestic (unspecified) 34
Bulldog - French 33
Unknown 29
Pug 27
Shih Tzu 27

Associated Drugs

Cefovecin 102
Maropitant Citrate 99
Moxidectin 90
Milbemycin Oxime + Spinosad 61
Furosemide 61
Dexamethasone 59
Melarsomine Dihydrochloride 55
Prednisone 55
Bedinvetmab 53
Buprenorphine 46
Gabapentin 46
Enrofloxacin 42
Butorphanol 42
Carprofen 40
Doxycycline 36
Oclacitinib Maleate 35
Selamectin 34
Diphenhydramine Hcl 32
Dexmedetomidine Hydrochloride 30
Spinosad 30

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Respiratory distress, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,259 here).

Similar death-coded share

Nearest other reactions by death-coded share (59.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Respiratory distress (#326 of 2,481 by report volume); death-coded 59.6%. PlainBreed reaction plate · death-coded report count stamp 750 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →