Reaction profile

The FDA adverse-event record for respiratory distress

1,210 FDA adverse-event reports reference respiratory distress (VeDDRA 840). See the species, breeds, and drugs most associated with it below.

1,210
reports citing this reaction
60.0%
death-coded share
Dog
most-affected species
Cefovecin
most-associated drug
Verify with FDA CVM →
1,210
Total Reports
726
Deaths
60.0%
Death Rate

Species Most Affected

Dog 725
Cat 321
Cattle 92
Horse 27
Human 20
Pig 10
Ferret 3
Sheep 2
Other Birds 2
Rabbit 2

Breeds Most Affected

Domestic Shorthair 160
Retriever - Labrador 58
Crossbred Canine/dog 51
Terrier - Yorkshire 38
Chihuahua 37
Domestic (unspecified) 34
Bulldog - French 32
Unknown 29
Pug 27
Domestic Longhair 26

Associated Drugs

Cefovecin 101
Maropitant Citrate 96
Moxidectin 86
Milbemycin Oxime + Spinosad 61
Furosemide 58
Dexamethasone 57
Melarsomine Dihydrochloride 53
Prednisone 50
Bedinvetmab 45
Buprenorphine 41
Carprofen 39
Enrofloxacin 39
Butorphanol 39
Gabapentin 38
Oclacitinib Maleate 35
Selamectin 33
Doxycycline 33
Diphenhydramine Hcl 32
Spinosad 30
Afoxolaner 30

Respiratory distress Reaction Insights

1,210 reports name Respiratory distress; 726 recorded a death outcome (60.0% of reported events, not a population-level mortality rate). VeDDRA code: 840.

By species: Dog (725 reports), Cat (321 reports), Cattle (92 reports). By breed: Domestic Shorthair (160), Retriever - Labrador (58), Crossbred Canine/dog (51).

Most co-reported drugs: Cefovecin (101 reports), Maropitant Citrate (96 reports), Moxidectin (86 reports), Milbemycin Oxime + Spinosad (61 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.