Reaction profile

The FDA adverse-event record for stomach upset

1,266 FDA reports name stomach upset, a high-volume reaction in the CVM extract (VeDDRA 1800). Plate stamps and neighbourhood peers follow.

#324 of 2,481
by report volume (all reactions)
1,266
reports citing this reaction
4.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Stomach upset has 1,266 reports now versus 1,244 in that prior snapshot: 22 more (1.8%).

Report change
+22
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Stomach upset changes

FDA AER · VeDDRA plate

Code 1800 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,266 reports
  • DEATH-LOW 4.2%
  • UPPER-Q #324/2481
  • PHOTO-FINISH Incorrect route of dr…
  • SPECIES-DOG Dog · 1,109
  • DRUG-LEAD Milbemycin Oxime… · 302
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Incorrect route of drug administration (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Stomach upset

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site infl… · near1270NT - Abnormal necrops… · near1268Stomach upset · this reaction1266Incorrect route of dr… · near1264Respiratory distress · near1259Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Stomach upset

Stomach upset: low death-coded share in the FDA AER plate

Signature read: 1,266 reports place Stomach upset in the upper third of FDA AER volume (#324 of 2,481). Report volume is upper-third scale: 1,266 named reports in the openFDA extract. Death-coded share is lower-third: 53 of 1,266 reports (4.2% of named reports). Nearest volume peer: Incorrect route of drug administration (±2 reports). Lead species Dog (1,109). Lead co-reported drug Milbemycin Oxime + Spinosad (302).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,109
Human 107
Cat 41
Horse 5
Cattle 3
Other 1

Breeds Most Affected

Unknown 113
Dog (unknown) 113
Retriever - Labrador 98
Crossbred Canine/dog 70
Terrier - Yorkshire 55
Chihuahua 50
Retriever - Golden 39
Shih Tzu 39
Shepherd Dog - German 34
Boxer (German Boxer) 28

Associated Drugs

Milbemycin Oxime + Spinosad 302
Ivermectin + Pyrantel As Pamoate Salt 102
Pyrantel Pamoate;Sarolaner 97
Afoxolaner 89
Milbemycin Oxime + Praziquantel 83
Spinosad 72
Carprofen 58
Oclacitinib Maleate 55
Grapiprant 48
Lotilaner 43
Maropitant Citrate 39
Cyclosporine 30
Fluralaner 13.64% 12-Week Chew 30
Trilostane 29
Fluralaner Chew Tablets 28
Nitenpyram 26
Metronidazole 24
Ivermectin 23
Bedinvetmab 22
Polysulfated Glycosaminoglycan 21

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Stomach upset, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (4.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Stomach upset (#324 of 2,481 by report volume); death-coded 4.2%. PlainBreed reaction plate · report volume stamp 1,266 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →