Reaction profile

The FDA adverse-event record for incorrect route of drug administration

1,215 FDA adverse-event reports reference incorrect route of drug administration (VeDDRA 99837). See the species, breeds, and drugs most associated with it below.

1,215
reports citing this reaction
6.1%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
1,215
Total Reports
74
Deaths
6.1%
Death Rate

Species Most Affected

Dog 664
Cat 450
Cattle 33
Human 24
Horse 23
Sheep 4
Pig 4
Chicken 2
Other 1
Goat 1

Breeds Most Affected

Domestic Shorthair 242
Cat (unknown) 83
Dog (unknown) 65
Retriever - Labrador 60
Crossbred Canine/dog 48
Chihuahua 39
Domestic Longhair 35
Shih Tzu 29
Retriever - Golden 29
Unknown 28

Associated Drugs

Imidacloprid + Moxidectin 192
Polysulfated Glycosaminoglycan 108
Eprinomectin + Esafoxolaner + Praziquantel 84
Selamectin 77
Emodepside + Praziquantel 76
Methylprednisolone Acetate 47
Prednisone 47
Desoxycortone 47
Genta/Momet/Clotrim Ear Oint 41
Eprinomectin + Praziquantel 40
Atipamezole Hydrochloride 39
Carprofen 38
Tiletamine Hcl; Zolazapam Hcl 35
Cefovecin 30
Dexmedetomidine Hydrochloride 24
Meloxicam 24
Desoxycorticosterone Pivalate 23
Butorphanol 23
Maropitant Citrate 22
Isoflurane 22

Incorrect route of drug administration Reaction Insights

1,215 reports name Incorrect route of drug administration; 74 recorded a death outcome (6.1% of reported events, not a population-level mortality rate). VeDDRA code: 99837.

By species: Dog (664 reports), Cat (450 reports), Cattle (33 reports). By breed: Domestic Shorthair (242), Cat (unknown) (83), Dog (unknown) (65).

Most co-reported drugs: Imidacloprid + Moxidectin (192 reports), Polysulfated Glycosaminoglycan (108 reports), Eprinomectin + Esafoxolaner + Praziquantel (84 reports), Selamectin (77 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.