Reaction profile

The FDA adverse-event record for fatty liver

71 FDA adverse-event reports reference fatty liver (VeDDRA 483). See the species, breeds, and drugs most associated with it below.

71
reports citing this reaction
57.7%
death-coded share
Cat
most-affected species
Cyclosporine A
most-associated drug
Verify with FDA CVM →
71
Total Reports
41
Deaths
57.7%
Death Rate

Species Most Affected

Cat 43
Dog 19
Cattle 7
Chicken 1
Goat 1

Breeds Most Affected

Domestic Shorthair 26
Domestic Longhair 5
Domestic Mediumhair 3
Cat (unknown) 3
Holstein-Friesian also known as Holstein 3
Retriever - Labrador 3
Cattle (unknown) 2
Schnauzer - Miniature 1
Rottweiler 1
Terrier - Yorkshire 1

Associated Drugs

Cyclosporine A 11
Spinosad 6
Prednisone 5
Imidacloprid + Moxidectin 4
Monensin Sodium 4
Emodepside + Praziquantel 3
Maropitant Citrate 3
Acepromazine 3
Selamectin 3
Fluralaner Chew Tablets 3
Rabies Vaccine 3
Cyclosporine 3
Dexamethasone + Neomycin Sulfate + Thiabendazole 3
Enrofloxacin 2
Isoflurane 2
Milbemycin Oxime + Spinosad 2
Fluids 2
Robenacoxib 2
Cefovecin 2
Carprofen 2

Fatty liver Reaction Insights

71 reports name Fatty liver; 41 recorded a death outcome (57.7% of reported events, not a population-level mortality rate). VeDDRA code: 483.

By species: Cat (43 reports), Dog (19 reports), Cattle (7 reports). By breed: Domestic Shorthair (26), Domestic Longhair (5), Domestic Mediumhair (3).

Most co-reported drugs: Cyclosporine A (11 reports), Spinosad (6 reports), Prednisone (5 reports), Imidacloprid + Moxidectin (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.