Reaction profile

The FDA adverse-event record for circulatory shock

97 FDA adverse-event reports reference circulatory shock (VeDDRA 221). See the species, breeds, and drugs most associated with it below.

97
reports citing this reaction
57.7%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
97
Total Reports
56
Deaths
57.7%
Death Rate

Species Most Affected

Dog 84
Cat 8
Horse 3
Other Rodents 1
Other 1

Breeds Most Affected

Retriever - Labrador 10
Shepherd Dog - German 5
Dog (unknown) 5
Collie - Border 5
Dachshund (unspecified) 5
Rottweiler 4
Unknown 4
Chihuahua 3
Terrier - Jack Russell 3
Shih Tzu 3

Associated Drugs

Moxidectin 20
Maropitant Citrate 9
Deracoxib 8
Isoflurane 7
Milbemycin Oxime + Spinosad 6
Dexamethasone 5
Dexmedetomidine Hydrochloride 5
Prednisone 4
Bordetella Bronchiseptica, Strain 78-9159, Kb 4
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 4
Tramadol 4
Buprenorphine 4
Carprofen 4
Melarsomine Dihydrochloride 4
Diphenhydramine Hcl 3
Cefovecin 3
Butorphanol 3
Afoxolaner 3
Furosemide 3
Rabies Virus, 3

Circulatory shock Reaction Insights

97 reports name Circulatory shock; 56 recorded a death outcome (57.7% of reported events, not a population-level mortality rate). VeDDRA code: 221.

By species: Dog (84 reports), Cat (8 reports), Horse (3 reports). By breed: Retriever - Labrador (10), Shepherd Dog - German (5), Dog (unknown) (5).

Most co-reported drugs: Moxidectin (20 reports), Maropitant Citrate (9 reports), Deracoxib (8 reports), Isoflurane (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.