Reaction profile

The FDA adverse-event record for rash

2,286 FDA adverse-event reports reference rash (VeDDRA 939). See the species, breeds, and drugs most associated with it below.

2,286
reports citing this reaction
1.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,286
Total Reports
44
Deaths
1.9%
Death Rate

Species Most Affected

Dog 1,875
Human 272
Cat 124
Horse 7
Cattle 3
Pig 2
Other 1
Monkey 1
Ferret 1

Breeds Most Affected

Unknown 278
Crossbred Canine/dog 149
Retriever - Labrador 131
Chihuahua 108
Dog (unknown) 97
Pit Bull 95
Terrier - Yorkshire 79
Retriever - Golden 70
Shepherd Dog - German 66
Domestic Shorthair 65

Associated Drugs

Milbemycin Oxime + Spinosad 380
Afoxolaner 268
Spinosad 212
Selamectin 166
Ivermectin + Pyrantel As Pamoate Salt 118
Imidacloprid + Moxidectin 112
Pyrantel Pamoate;Sarolaner 97
Oclacitinib Maleate 78
Moxidectin 64
Milbemycin Oxime + Praziquantel 62
Nitenpyram 58
Fluralaner Chew Tablets 57
Fluralaner 13.64% 12-Week Chew 50
Prednisone 45
Carprofen 42
Maropitant Citrate 37
Ivermectin 35
Sarolaner 33
Lotilaner 29
Anti-Il31 Mab Mcs Lot #1283563 24

Rash Reaction Insights

2,286 reports name Rash; 44 recorded a death outcome (1.9% of reported events, not a population-level mortality rate). VeDDRA code: 939.

By species: Dog (1,875 reports), Human (272 reports), Cat (124 reports). By breed: Unknown (278), Crossbred Canine/dog (149), Retriever - Labrador (131).

Most co-reported drugs: Milbemycin Oxime + Spinosad (380 reports), Afoxolaner (268 reports), Spinosad (212 reports), Selamectin (166 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.