Reaction profile

The FDA adverse-event record for blood in faeces

2,262 FDA adverse-event reports reference blood in faeces (VeDDRA 1081). See the species, breeds, and drugs most associated with it below.

2,262
reports citing this reaction
11.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,262
Total Reports
250
Deaths
11.1%
Death Rate

Species Most Affected

Dog 2,116
Cat 110
Cattle 20
Horse 7
Human 5
Chicken 2
Pig 1
Other Rodents 1

Breeds Most Affected

Retriever - Labrador 194
Crossbred Canine/dog 152
Chihuahua 96
Terrier - Yorkshire 89
Retriever - Golden 80
Beagle 75
Shih Tzu 70
Dog (unknown) 68
Domestic Shorthair 67
Dachshund (unspecified) 55

Associated Drugs

Milbemycin Oxime + Spinosad 227
Ivermectin + Pyrantel As Pamoate Salt 213
Carprofen 204
Afoxolaner 122
Fluralaner Chew Tablets 115
Maropitant Citrate 113
Moxidectin 99
Grapiprant 91
Oclacitinib Maleate 89
Metronidazole 62
Spinosad 55
Imidacloprid + Moxidectin 54
Pyrantel Pamoate;Sarolaner 53
Milbemycin Oxime + Praziquantel 52
Bedinvetmab 52
Meloxicam 51
Lufenuron + Milbemycin Oxime 47
Trilostane 47
Milbemycin Oxime, Lufenuron 46
Selamectin 44

Blood in faeces Reaction Insights

2,262 reports name Blood in faeces; 250 recorded a death outcome (11.1% of reported events, not a population-level mortality rate). VeDDRA code: 1081.

By species: Dog (2,116 reports), Cat (110 reports), Cattle (20 reports). By breed: Retriever - Labrador (194), Crossbred Canine/dog (152), Chihuahua (96).

Most co-reported drugs: Milbemycin Oxime + Spinosad (227 reports), Ivermectin + Pyrantel As Pamoate Salt (213 reports), Carprofen (204 reports), Afoxolaner (122 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.