Reaction profile

The FDA adverse-event record for application site skin scaling

196 FDA adverse-event reports reference application site skin scaling (VeDDRA 2198). See the species, breeds, and drugs most associated with it below.

196
reports citing this reaction
2.0%
death-coded share
Cat
most-affected species
Mirtazapine
most-associated drug
Verify with FDA CVM →
196
Total Reports
4
Deaths
2.0%
Death Rate

Species Most Affected

Cat 147
Dog 36
Cattle 9
Horse 4

Breeds Most Affected

Domestic Shorthair 99
Domestic Longhair 12
Siamese 8
Bengal 7
Domestic Mediumhair 6
Cat (unknown) 4
Retriever - Labrador 3
Cat (other) 3
Cattle (other) 3
Shepherd (unspecified) 3

Associated Drugs

Mirtazapine 61
Selamectin 26
Selamectin;Sarolaner 20
Fluralaner Spot-On Solution 16
Emodepside + Praziquantel 13
Imidacloprid + Moxidectin 11
Flunixin Megl Topical Solution 7
Maropitant 6
Ivermectin + Pyrantel As Pamoate Salt 5
Prednisolone 5
Fluralaner/Moxidectin Spot-On 5
Buprenorphine 5
Eprinomectin + Esafoxolaner + Praziquantel 5
Fipronil 10%/S Methoprene 9% Spot On 4
Prednisone 4
Famotidine 4
Maropitant Citrate 4
Methimazole 4
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3

Application site skin scaling Reaction Insights

196 reports name Application site skin scaling; 4 recorded a death outcome (2.0% of reported events, not a population-level mortality rate). VeDDRA code: 2198.

By species: Cat (147 reports), Dog (36 reports), Cattle (9 reports). By breed: Domestic Shorthair (99), Domestic Longhair (12), Siamese (8).

Most co-reported drugs: Mirtazapine (61 reports), Selamectin (26 reports), Selamectin;Sarolaner (20 reports), Fluralaner Spot-On Solution (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.