Reaction profile

The FDA adverse-event record for elevated lactate

144 FDA adverse-event reports reference elevated lactate (VeDDRA 2852). See the species, breeds, and drugs most associated with it below.

144
reports citing this reaction
47.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
144
Total Reports
68
Deaths
47.2%
Death Rate

Species Most Affected

Dog 109
Cat 25
Horse 10

Breeds Most Affected

Retriever - Labrador 17
Crossbred Canine/dog 14
Domestic Shorthair 12
Retriever - Golden 6
Shepherd Dog - Australian 4
Maltese 4
Mustang 3
Domestic Mediumhair 3
Pug 3
Shih Tzu 3

Associated Drugs

Maropitant Citrate 33
Gabapentin 33
Carprofen 26
Enrofloxacin 20
Propofol 18
Rabies Vaccine 11
Bedinvetmab 11
Omeprazole 10
Isoflurane 10
Butorphanol 10
Famotidine 10
Fentanyl 10
Hydromorphone 10
Midazolam 10
Buprenorphine 10
Pyrantel Pamoate;Sarolaner 9
Ondansetron 9
Dextrose 9
Pantoprazole 9
Oxygen 9

Elevated lactate Reaction Insights

144 reports name Elevated lactate; 68 recorded a death outcome (47.2% of reported events, not a population-level mortality rate). VeDDRA code: 2852.

By species: Dog (109 reports), Cat (25 reports), Horse (10 reports). By breed: Retriever - Labrador (17), Crossbred Canine/dog (14), Domestic Shorthair (12).

Most co-reported drugs: Maropitant Citrate (33 reports), Gabapentin (33 reports), Carprofen (26 reports), Enrofloxacin (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.