Reaction profile

The FDA adverse-event record for hemoglobin(hb) high, blood

175 FDA adverse-event reports reference hemoglobin(hb) high, blood (VeDDRA 99310). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1106 of 2,481
by report volume (all reactions)
175
reports citing this reaction
13.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. HEMOGLOBIN(HB) HIGH, BLOOD has 175 reports now versus 175 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to HEMOGLOBIN(HB) HIGH, BLOOD changes

FDA AER · VeDDRA plate

Code 99310 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 175 reports
  • DEATH-ELEV 13.7%
  • MID-PACK #1106/2481
  • PHOTO-FINISH Elevated lactate
  • SPECIES-DOG Dog · 164
  • DRUG-LEAD Milbemycin Oxime… · 36
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated lactate (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around HEMOGLOBIN HIGH, BLOOD

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Elevated lactate · near175HEMOGLOBIN(HB) HIGH,… · this…175Hepatic neoplasm · near175PR-LYMPH NODE(S), LES… · near175Premature ventricular… · near175Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around HEMOGLOBIN(HB) HIGH, BLOOD

What the FDA AER plate says about HEMOGLOBIN(HB) HIGH, BLOOD

Signature read: 24 death-coded reports is the most distinctive absolute-outcome stamp on HEMOGLOBIN(HB) HIGH, BLOOD. Report volume sits in the middle third of the reaction corpus. 24 of 175 reports were death-coded (13.7% of named reports, not a population mortality rate). Nearest volume peer: Elevated lactate (±0 reports). Lead species Dog (164). Lead co-reported drug Milbemycin Oxime + Spinosad (36).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 164
Cat 8
Horse 3

Breeds Most Affected

Retriever - Labrador 19
Crossbred Canine/dog 10
Greyhound 8
Shepherd Dog - German 6
Maltese 6
Pit Bull 6
Chihuahua 5
Bulldog 5
Boxer (German Boxer) 4
Domestic Shorthair 4

Associated Drugs

Milbemycin Oxime + Spinosad 36
Ivermectin + Pyrantel As Pamoate Salt 27
Afoxolaner 13
Fluralaner 13.64% 12-Week Chew 10
Trilostane 7
Polysulfated Glycosaminoglycan 7
Moxidectin 6
Firocoxib 6
Fluralaner Chew Tablets 6
Rabies Vaccine 6
Carprofen 5
Lotilaner 5
Bordetella Vaccine 4
Fentanyl 4
Gabapentin 4
Pyrantel Pamoate;Sarolaner 4
Milbemycin Oxime + Praziquantel 4
Milbemycin/Lufenuron Tablets 4
Imidacloprid + Moxidectin 3
Cyclosporine A 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for HEMOGLOBIN(HB) HIGH, BLOOD, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (13.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for HEMOGLOBIN(HB) HIGH, BLOOD (#1106 of 2,481 by report volume); death-coded 13.7%. PlainBreed reaction plate · death-coded report count stamp 24 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →