Reaction profile

The FDA adverse-event record for hemoglobin(hb) high, blood

175 FDA adverse-event reports reference hemoglobin(hb) high, blood (VeDDRA 99310). See the species, breeds, and drugs most associated with it below.

175
reports citing this reaction
13.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
175
Total Reports
24
Deaths
13.7%
Death Rate

Species Most Affected

Dog 164
Cat 8
Horse 3

Breeds Most Affected

Retriever - Labrador 19
Crossbred Canine/dog 10
Greyhound 8
Shepherd Dog - German 6
Maltese 6
Pit Bull 6
Chihuahua 5
Bulldog 5
Boxer (German Boxer) 4
Domestic Shorthair 4

Associated Drugs

Milbemycin Oxime + Spinosad 36
Ivermectin + Pyrantel As Pamoate Salt 27
Afoxolaner 13
Fluralaner 13.64% 12-Week Chew 10
Trilostane 7
Polysulfated Glycosaminoglycan 7
Moxidectin 6
Firocoxib 6
Fluralaner Chew Tablets 6
Rabies Vaccine 6
Carprofen 5
Lotilaner 5
Bordetella Vaccine 4
Fentanyl 4
Gabapentin 4
Pyrantel Pamoate;Sarolaner 4
Milbemycin/Lufenuron Tablets 4
Milbemycin Oxime + Praziquantel 4
Imidacloprid + Moxidectin 3
Cyclosporine A 3

HEMOGLOBIN(HB) HIGH, BLOOD Reaction Insights

175 reports name HEMOGLOBIN(HB) HIGH, BLOOD; 24 recorded a death outcome (13.7% of reported events, not a population-level mortality rate). VeDDRA code: 99310.

By species: Dog (164 reports), Cat (8 reports), Horse (3 reports). By breed: Retriever - Labrador (19), Crossbred Canine/dog (10), Greyhound (8).

Most co-reported drugs: Milbemycin Oxime + Spinosad (36 reports), Ivermectin + Pyrantel As Pamoate Salt (27 reports), Afoxolaner (13 reports), Fluralaner 13.64% 12-Week Chew (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.