Reaction profile

The FDA adverse-event record for hepatic neoplasm

172 FDA adverse-event reports reference hepatic neoplasm (VeDDRA 507). See the species, breeds, and drugs most associated with it below.

172
reports citing this reaction
65.7%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
172
Total Reports
113
Deaths
65.7%
Death Rate

Species Most Affected

Dog 164
Cat 7
Horse 1

Breeds Most Affected

Retriever - Labrador 22
Dog (unknown) 15
Retriever - Golden 12
Crossbred Canine/dog 11
Shepherd Dog - Australian 9
Schnauzer (unspecified) 6
Beagle 6
Terrier - Yorkshire 5
Shepherd Dog - German 5
Shih Tzu 4

Associated Drugs

Oclacitinib Maleate 31
Trilostane 26
Carprofen 22
Milbemycin Oxime + Spinosad 16
Spinosad 10
Maropitant Citrate 8
Polysulfated Glycosaminoglycan 7
Afoxolaner 7
Grapiprant 7
Meloxicam 6
Fluralaner Chew Tablets 6
Moxidectin 5
Ivermectin 5
Deracoxib 4
Cyclosporine 4
Ivermectin + Pyrantel As Pamoate Salt 4
Tramadol 4
Milbemycin Oxime 4
Anti-Il31 Mab Mcs Lot #1283563 4
Milbemycin Oxime + Praziquantel 4

Hepatic neoplasm Reaction Insights

172 reports name Hepatic neoplasm; 113 recorded a death outcome (65.7% of reported events, not a population-level mortality rate). VeDDRA code: 507.

By species: Dog (164 reports), Cat (7 reports), Horse (1 reports). By breed: Retriever - Labrador (22), Dog (unknown) (15), Retriever - Golden (12).

Most co-reported drugs: Oclacitinib Maleate (31 reports), Trilostane (26 reports), Carprofen (22 reports), Milbemycin Oxime + Spinosad (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.