Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - mannheimia haemolytica

41 FDA adverse-event reports reference lack of efficacy (bacteria) - mannheimia haemolytica (VeDDRA 2995). See the species, breeds, and drugs most associated with it below.

41
reports citing this reaction
92.7%
death-coded share
Cattle
most-affected species
Tulathromycin
most-associated drug
Verify with FDA CVM →
41
Total Reports
38
Deaths
92.7%
Death Rate

Species Most Affected

Cattle 41

Breeds Most Affected

Mixed (Cattle) 25
Cattle (other) 10
Cattle (unknown) 2
Crossbred Bovine/Cattle 1
Aberdeen Angus 1
Simmental 1
Salers 1

Associated Drugs

Tulathromycin 17
Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 14
Ceftiofur Crystalline Free Acid 11
Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti 8
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D;Bovine Viral Di 5
Mannheimia Haemolytica, Strain Nl-1009 5
Gamithromycin 4
Ketoprofen;Tulathromycin 4
Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 4
Oxfendazole 4
Bovine Viral Diarrhea Virus, Type 1, Strain Nadl-Sbvd, Msvx+1;Bovine Viral Diarr 4
Florfenicol/Flunixin Inj-Triac 3
Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid 3
Ceftiofur Hydrochloride 3
Clostridial And H. Somnus Vaccine 3
Tildipirosin Injectable 2
Bovine Virus*5/Past M+Mh Lv/Lb 2
Clostridium Chauvoei, Strain F, Lot No. 2-84;Clostridium Novyi, 8296 2
Mycoplasma Bovis 2
Moxidectin 1

Lack of efficacy (bacteria) - Mannheimia haemolytica Reaction Insights

41 reports name Lack of efficacy (bacteria) - Mannheimia haemolytica; 38 recorded a death outcome (92.7% of reported events, not a population-level mortality rate). VeDDRA code: 2995.

By species: Cattle (41 reports). By breed: Mixed (Cattle) (25), Cattle (other) (10), Cattle (unknown) (2).

Most co-reported drugs: Tulathromycin (17 reports), Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus (14 reports), Ceftiofur Crystalline Free Acid (11 reports), Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.