Reaction profile

The FDA adverse-event record for pr-liver, lesion(s)

767 FDA adverse-event reports reference pr-liver, lesion(s) (VeDDRA 99629). See the species, breeds, and drugs most associated with it below.

767
reports citing this reaction
81.6%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
767
Total Reports
626
Deaths
81.6%
Death Rate

Species Most Affected

Dog 536
Cat 147
Cattle 62
Horse 8
Other Birds 2
Pig 2
Donkey 1
Guinea Pig 1
Buffalo 1
Chicken 1

Breeds Most Affected

Retriever - Labrador 103
Domestic (unspecified) 66
Crossbred Canine/dog 61
Domestic Shorthair 44
Retriever - Golden 34
Holstein-Friesian also known as Holstein 25
Shepherd Dog - German 15
Shih Tzu 14
Shepherd Dog - Australian 14
Boxer (German Boxer) 13

Associated Drugs

Carprofen 150
Maropitant Citrate 62
Fluralaner Chew Tablets 44
Milbemycin Oxime + Spinosad 43
Oclacitinib Maleate 38
Cefovecin Sodium 36
Moxidectin 33
Afoxolaner 31
Spinosad 30
Deracoxib 29
Cefovecin 29
Maropitant 25
Meloxicam 21
Dexmedetomidine Hydrochloride 19
Enrofloxacin 19
Famotidine 19
Robenacoxib 18
Tramadol 18
Dexamethasone 16
Sam-E, Silybin, Vitamin E, Zinc 16

PR-LIVER, LESION(S) Reaction Insights

767 reports name PR-LIVER, LESION(S); 626 recorded a death outcome (81.6% of reported events, not a population-level mortality rate). VeDDRA code: 99629.

By species: Dog (536 reports), Cat (147 reports), Cattle (62 reports). By breed: Retriever - Labrador (103), Domestic (unspecified) (66), Crossbred Canine/dog (61).

Most co-reported drugs: Carprofen (150 reports), Maropitant Citrate (62 reports), Fluralaner Chew Tablets (44 reports), Milbemycin Oxime + Spinosad (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.