Reaction profile

The FDA adverse-event record for acute mastitis

54 FDA reports name acute mastitis, a lower-volume reaction in the CVM extract (VeDDRA 525). Plate stamps and neighbourhood peers follow.

#1696 of 2,481
by report volume (all reactions)
54
reports citing this reaction
81.5%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Acute mastitis has 54 reports now versus 54 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Acute mastitis changes

FDA AER · VeDDRA plate

Code 525 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 54 reports
  • DEATH-HOT 81.5%
  • MID-PACK #1696/2481
  • PHOTO-FINISH Arthropathy NOS
  • SPECIES-CATTLE Cattle · 46
  • DRUG-LEAD Cloxacillin Benza… · 21
  • DESK-WIDE 9 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Arthropathy NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Acute mastitis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Acute mastitis · this reacti…54Arthropathy NOS · near54Exophthalmia · near54Hypovolaemic shock · near54INEFFECTIVE, COGNITIV… · near54Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Acute mastitis

Acute mastitis: high death-coded share in the FDA AER plate

Signature read: Acute mastitis's 81.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 54 named reports in the openFDA extract. Death-coded share is upper-third: 44 of 54 reports (81.5% of named reports). Nearest volume peer: Arthropathy NOS (±0 reports). Lead species Cattle (46). Lead co-reported drug Cloxacillin Benzathine (21).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 46
Dog 4
Horse 2
Goat 2

Breeds Most Affected

Holstein-Friesian also known as Holstein 31
Cattle (other) 8
Jersey 5
Shepherd Dog - German 3
Cattle (unknown) 2
Goat (unknown) 2
Quarter Horse 1
Connemara Pony 1
Corgi - Welsh Pembroke 1

Associated Drugs

Cloxacillin Benzathine 21
Cephapirin Benzathine 17
Bismuth Subnitrate 60% Intramammary 8
Pirlimycin Hydrochloride 6
Carprofen 2
Tiletamine, Zolazepam 1
Domperidone 1
Dihydrostreptomycin Sulfate; Procaine Penicillin 1
Bismuth Subnitrate 1
E. Coli Strain J5, Lot #072692 1
Alcohol Wipes 1
Teat Sealant 1
Bovine Rhinotracheitis Virus Diarrhea Pi3 Rsv Vac, Killed Virus, Lcghip Bacterin 1
Bovine Rhinotracheitis Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Kv, Leptospira Canicola-Grippotyphosa-Hardjo-Ictero-Pomona-Bacterin 1
Ceftiofur Hydrochloride 1
Monensin Sodium 1
Altrenogest Oily Solution 1
Cloxacillin Benz Intramam Dc 1
Bismuth Subnitrate, Mineral Oil 1
Salmonella Typhimurium Bacterin Toxoid 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Acute mastitis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (54 here).

Similar death-coded share

Nearest other reactions by death-coded share (81.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Acute mastitis (#1696 of 2,481 by report volume); death-coded 81.5%. PlainBreed reaction plate · death-coded share stamp 81.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →