Reaction profile

The FDA adverse-event record for hair shedding

774 FDA reports name hair shedding, a high-volume reaction in the CVM extract (VeDDRA 1971). Plate stamps and neighbourhood peers follow.

#469 of 2,481
by report volume (all reactions)
774
reports citing this reaction
2.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hair shedding has 774 reports now versus 760 in that prior snapshot: 14 more (1.8%).

Report change
+14
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hair shedding changes

FDA AER · VeDDRA plate

Code 1971 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 774 reports
  • DEATH-LOW 2.7%
  • UPPER-Q #469/2481
  • PHOTO-FINISH Hepatopathy
  • SPECIES-DOG Dog · 656
  • DRUG-LEAD Milbemycin Oxime… · 84
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hepatopathy (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hair shedding

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Diabetes · near777Skin and tissue infec… · near777Hair shedding · this reaction774Hepatopathy · near774PR-LIVER, LESION(S) · near772Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hair shedding

Hair shedding: low death-coded share in the FDA AER plate

Signature read: Hair shedding's 2.7% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 774 named reports in the openFDA extract. Death-coded share is lower-third: 21 of 774 reports (2.7% of named reports). Nearest volume peer: Hepatopathy (±0 reports). Lead species Dog (656). Lead co-reported drug Milbemycin Oxime + Spinosad (84).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 656
Cat 109
Horse 4
Cattle 3
Unknown 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 120
Domestic Shorthair 60
Crossbred Canine/dog 53
Shepherd Dog - German 45
Retriever - Golden 42
Chihuahua 25
Dog (unknown) 25
Boxer (German Boxer) 19
Bulldog - French 16
Shepherd Dog - Australian 15

Associated Drugs

Milbemycin Oxime + Spinosad 84
Afoxolaner 84
Cyclosporine 67
Cyclosporine A 61
Trilostane 56
Oclacitinib Maleate 47
Carprofen 34
Spinosad 31
Bedinvetmab 31
Ivermectin + Pyrantel As Pamoate Salt 29
Fluralaner Chew Tablets 29
Prednisone 25
Fluralaner Spot-On Solution 25
Imidacloprid + Moxidectin 18
Selamectin 17
Pyrantel Pamoate;Sarolaner 16
Ketoconazole 14
Levothyroxine Sodium 13
Sarolaner 12
Emodepside + Praziquantel 10

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hair shedding, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (774 here).

Similar death-coded share

Nearest other reactions by death-coded share (2.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hair shedding (#469 of 2,481 by report volume); death-coded 2.7%. PlainBreed reaction plate · death-coded share stamp 2.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →