Reaction profile

The FDA adverse-event record for hair shedding

753 FDA adverse-event reports reference hair shedding (VeDDRA 1971). See the species, breeds, and drugs most associated with it below.

753
reports citing this reaction
2.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
753
Total Reports
20
Deaths
2.7%
Death Rate

Species Most Affected

Dog 637
Cat 107
Horse 4
Cattle 3
Unknown 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 118
Domestic Shorthair 60
Crossbred Canine/dog 51
Shepherd Dog - German 45
Retriever - Golden 42
Dog (unknown) 24
Chihuahua 23
Boxer (German Boxer) 18
Shepherd Dog - Australian 15
Bulldog 14

Associated Drugs

Milbemycin Oxime + Spinosad 84
Afoxolaner 82
Cyclosporine 67
Cyclosporine A 61
Trilostane 53
Oclacitinib Maleate 45
Spinosad 31
Carprofen 31
Ivermectin + Pyrantel As Pamoate Salt 29
Fluralaner Chew Tablets 29
Fluralaner Spot-On Solution 24
Bedinvetmab 24
Prednisone 21
Selamectin 17
Imidacloprid + Moxidectin 17
Pyrantel Pamoate;Sarolaner 16
Ketoconazole 14
Levothyroxine Sodium 13
Sarolaner 12
Emodepside + Praziquantel 10

Hair shedding Reaction Insights

753 reports name Hair shedding; 20 recorded a death outcome (2.7% of reported events, not a population-level mortality rate). VeDDRA code: 1971.

By species: Dog (637 reports), Cat (107 reports), Horse (4 reports). By breed: Retriever - Labrador (118), Domestic Shorthair (60), Crossbred Canine/dog (51).

Most co-reported drugs: Milbemycin Oxime + Spinosad (84 reports), Afoxolaner (82 reports), Cyclosporine (67 reports), Cyclosporine A (61 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.