Reaction profile

The FDA adverse-event record for diabetes mellitus

747 FDA adverse-event reports reference diabetes mellitus (VeDDRA 389). See the species, breeds, and drugs most associated with it below.

747
reports citing this reaction
14.9%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
747
Total Reports
111
Deaths
14.9%
Death Rate

Species Most Affected

Dog 627
Cat 120

Breeds Most Affected

Domestic Shorthair 63
Retriever - Labrador 61
Crossbred Canine/dog 37
Terrier - West Highland White 34
Terrier - Yorkshire 33
Schnauzer - Miniature 33
Chihuahua 31
Maltese 29
Bichon Frise 22
Shih Tzu 20

Associated Drugs

Trilostane 341
Oclacitinib Maleate 74
Cyclosporine 46
Cyclosporine A 38
Fluralaner Chew Tablets 38
Insulin 30
Milbemycin Oxime + Spinosad 28
Spinosad 25
Prednisone 25
Methylprednisolone Acetate 22
Cefovecin 22
Carprofen 20
Gabapentin 16
Bedinvetmab 16
Fluralaner 13.64% 12-Week Chew 15
Frunevetmab 15
Afoxolaner 14
Cefovecin Sodium 12
Moxidectin 12
Levothyroxine 12

Diabetes mellitus Reaction Insights

747 reports name Diabetes mellitus; 111 recorded a death outcome (14.9% of reported events, not a population-level mortality rate). VeDDRA code: 389.

By species: Dog (627 reports), Cat (120 reports). By breed: Domestic Shorthair (63), Retriever - Labrador (61), Crossbred Canine/dog (37).

Most co-reported drugs: Trilostane (341 reports), Oclacitinib Maleate (74 reports), Cyclosporine (46 reports), Cyclosporine A (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.