Reaction profile

The FDA adverse-event record for quiet

770 FDA reports name quiet, a high-volume reaction in the CVM extract (VeDDRA 2645). Plate stamps and neighbourhood peers follow.

#473 of 2,481
by report volume (all reactions)
770
reports citing this reaction
15.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Quiet has 770 reports now versus 734 in that prior snapshot: 36 more (4.9%).

Report change
+36
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Quiet changes

FDA AER · VeDDRA plate

Code 2645 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 770 reports
  • DEATH-ELEV 15.8%
  • UPPER-Q #473/2481
  • PHOTO-FINISH Diabetes mellitus
  • SPECIES-DOG Dog · 549
  • DRUG-LEAD Maropitant Citrate · 108
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Diabetes mellitus (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Quiet

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348PR-LIVER, LESION(S) · near772Diabetes mellitus · near770Quiet · this reaction770Crystalluria · near769Hypoadrenocorticism · near768Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Quiet

What the FDA AER plate says about Quiet

Signature read: 122 death-coded reports is a heavy tail count for Quiet in the CVM extract. Report volume is upper-third scale: 770 named reports in the openFDA extract. 122 of 770 reports were death-coded (15.8% of named reports, not a population mortality rate). Nearest volume peer: Diabetes mellitus (±0 reports). Lead species Dog (549). Lead co-reported drug Maropitant Citrate (108).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Maropitant Citrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 549
Cat 197
Horse 22
Pig 1
Parrot 1

Breeds Most Affected

Domestic Shorthair 128
Retriever - Labrador 76
Retriever - Golden 36
Crossbred Canine/dog 35
Chihuahua 22
Terrier - Yorkshire 22
Beagle 20
Shih Tzu 17
Shepherd Dog - Australian 16
Shepherd Dog - German 15

Associated Drugs

Maropitant Citrate 108
Buprenorphine 60
Pyrantel Pamoate;Sarolaner 54
Gabapentin 49
Carprofen 48
Bedinvetmab 41
Sarolaner 40
Moxidectin 35
Prednisone 31
Isoflurane 31
Fluid Therapy 30
Unspecified 29
Afoxolaner 28
Oclacitinib Maleate 28
Lotilaner 28
Fluralaner 13.64% 12-Week Chew 27
Trilostane 26
Meloxicam 24
Milbemycin Oxime + Praziquantel 24
Ivermectin + Pyrantel As Pamoate Salt 21

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Quiet, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (770 here).

Similar death-coded share

Nearest other reactions by death-coded share (15.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Quiet (#473 of 2,481 by report volume); death-coded 15.8%. PlainBreed reaction plate · death-coded report count stamp 122 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →