Reaction profile

The FDA adverse-event record for pr-intest, lesion(s)

149 FDA adverse-event reports reference pr-intest, lesion(s) (VeDDRA 99623). See the species, breeds, and drugs most associated with it below.

149
reports citing this reaction
81.9%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
149
Total Reports
122
Deaths
81.9%
Death Rate

Species Most Affected

Dog 86
Cat 29
Cattle 19
Pig 5
Horse 4
Chicken 4
Sheep 2

Breeds Most Affected

Holstein-Friesian also known as Holstein 13
Retriever - Labrador 12
Crossbred Canine/dog 11
Domestic Shorthair 10
Domestic (unspecified) 6
Chihuahua 6
Domestic Mediumhair 5
Shepherd Dog - German 4
Crossbred Bovine/Cattle 3
Terrier - West Highland White 3

Associated Drugs

Maropitant Citrate 18
Oclacitinib Maleate 12
Afoxolaner 11
Cefovecin Sodium 10
Moxidectin 9
Cefovecin 9
Milbemycin Oxime + Spinosad 8
Tildipirosin 8
Carprofen 7
Imidacloprid + Moxidectin 7
Ivermectin + Pyrantel As Pamoate Salt 7
Maropitant 6
Spinosad 6
Deracoxib 5
Famotidine 5
Metronidazole 4
Enrofloxacin 4
Dexamethasone 4
Fluralaner Chew Tablets 4
Vaccine 3

PR-INTEST, LESION(S) Reaction Insights

149 reports name PR-INTEST, LESION(S); 122 recorded a death outcome (81.9% of reported events, not a population-level mortality rate). VeDDRA code: 99623.

By species: Dog (86 reports), Cat (29 reports), Cattle (19 reports). By breed: Holstein-Friesian also known as Holstein (13), Retriever - Labrador (12), Crossbred Canine/dog (11).

Most co-reported drugs: Maropitant Citrate (18 reports), Oclacitinib Maleate (12 reports), Afoxolaner (11 reports), Cefovecin Sodium (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.