Reaction profile

The FDA adverse-event record for thrombosis

114 FDA adverse-event reports reference thrombosis (VeDDRA 156). See the species, breeds, and drugs most associated with it below.

114
reports citing this reaction
83.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
114
Total Reports
95
Deaths
83.3%
Death Rate

Species Most Affected

Dog 76
Cat 30
Horse 5
Cattle 3

Breeds Most Affected

Domestic Shorthair 23
Retriever - Labrador 7
Retriever - Golden 6
Rottweiler 4
Beagle 4
Collie - Border 4
Shepherd Dog - German 3
Crossbred Canine/dog 3
Domestic Longhair 3
Quarter Horse 2

Associated Drugs

Milbemycin Oxime + Spinosad 11
Maropitant Citrate 10
Carprofen 10
Afoxolaner 7
Gabapentin 7
Frunevetmab 7
Bedinvetmab 7
Trilostane 6
Deracoxib 5
Tramadol 5
Grapiprant 5
Polysulfated Glycosaminoglycan 4
Imidacloprid And Moxidectin 4
Midazolam 4
Fluralaner 13.64% 12-Week Chew 4
Enrofloxacin 3
Imidacloprid + Moxidectin 3
Fentanyl 3
Rabies Vaccine 3
Amoxicillin 3

Thrombosis Reaction Insights

114 reports name Thrombosis; 95 recorded a death outcome (83.3% of reported events, not a population-level mortality rate). VeDDRA code: 156.

By species: Dog (76 reports), Cat (30 reports), Horse (5 reports). By breed: Domestic Shorthair (23), Retriever - Labrador (7), Retriever - Golden (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (11 reports), Maropitant Citrate (10 reports), Carprofen (10 reports), Afoxolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.