Reaction profile

The FDA adverse-event record for foam in the nose

89 FDA adverse-event reports reference foam in the nose (VeDDRA 1178). See the species, breeds, and drugs most associated with it below.

89
reports citing this reaction
65.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
89
Total Reports
58
Deaths
65.2%
Death Rate

Species Most Affected

Dog 40
Cattle 37
Horse 7
Cat 3
Donkey 1
Sheep 1

Breeds Most Affected

Aberdeen Angus 11
Cattle (other) 7
Crossbred Canine/dog 6
Chihuahua 5
Holstein-Friesian also known as Holstein 5
Bulldog - French 4
Terrier - Yorkshire 4
Cattle (unknown) 3
Maltese 3
Domestic Shorthair 3

Associated Drugs

Milbemycin Oxime + Spinosad 7
Spinosad 5
Bovine Virus*5/Past M+Mh Lv/Lb 5
Flunixin Meglumine Injectable 4
Maropitant Citrate 4
Afoxolaner 4
Clos P*2/Cl Oth*4/H.Somnus Kb 4
Vit E/ Selenite Inj Solution 4
Fenbendazol Suspension 4
Pimobendan 3
Zeranol Implant 3
Clos P*2/Cl Oth*4/Mor Bovis Kb 3
Ceftiofur Crystalline Free Acid 3
Fluralaner Chew Tablets 3
Canine Bb/Pi3/Adeno 2 Lv/Lb 3
Eprinomectin 3
Doramectin 2
Deracoxib 2
Tulathromycin 2
Flunixin Meglumine 2

Foam in the nose Reaction Insights

89 reports name Foam in the nose; 58 recorded a death outcome (65.2% of reported events, not a population-level mortality rate). VeDDRA code: 1178.

By species: Dog (40 reports), Cattle (37 reports), Horse (7 reports). By breed: Aberdeen Angus (11), Cattle (other) (7), Crossbred Canine/dog (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Spinosad (5 reports), Bovine Virus*5/Past M+Mh Lv/Lb (5 reports), Flunixin Meglumine Injectable (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.