Reaction profile

The FDA adverse-event record for dysphoria

626 FDA adverse-event reports reference dysphoria (VeDDRA 2531). See the species, breeds, and drugs most associated with it below.

626
reports citing this reaction
7.2%
death-coded share
Cat
most-affected species
Buprenorphine
most-associated drug
Verify with FDA CVM →
626
Total Reports
45
Deaths
7.2%
Death Rate

Species Most Affected

Cat 496
Dog 129
Horse 1

Breeds Most Affected

Domestic Shorthair 229
Cat (unknown) 163
Domestic Longhair 29
Domestic Mediumhair 19
Retriever - Labrador 13
Siamese 13
Dog (unknown) 12
Maine Coon 12
Crossbred Canine/dog 9
Chihuahua 7

Associated Drugs

Buprenorphine 519
Isoflurane 118
Robenacoxib 85
Propofol 83
Ketamine 83
Dexmedetomidine 78
Midazolam 68
Maropitant Citrate 65
Butorphanol 64
Cefovecin Sodium 41
Gabapentin 38
Anesthetic (Unknown) 34
Hydromorphone 30
Fluid Therapy 26
Meloxicam 24
Alfaxalone 24
Butorphanol Tartrate 23
Acepromazine 23
Sevoflurane 22
Bupivacaine 21

Dysphoria Reaction Insights

626 reports name Dysphoria; 45 recorded a death outcome (7.2% of reported events, not a population-level mortality rate). VeDDRA code: 2531.

By species: Cat (496 reports), Dog (129 reports), Horse (1 reports). By breed: Domestic Shorthair (229), Cat (unknown) (163), Domestic Longhair (29).

Most co-reported drugs: Buprenorphine (519 reports), Isoflurane (118 reports), Robenacoxib (85 reports), Propofol (83 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.