Reaction profile

The FDA adverse-event record for skin slough

695 FDA adverse-event reports reference skin slough (VeDDRA 943). See the species, breeds, and drugs most associated with it below.

695
reports citing this reaction
12.9%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
695
Total Reports
90
Deaths
12.9%
Death Rate

Species Most Affected

Dog 522
Cat 91
Horse 59
Cattle 8
Human 6
Fish 2
Pig 2
Goat 2
Guinea Pig 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 53
Retriever - Labrador 47
Dog (unknown) 36
Chihuahua 32
Crossbred Canine/dog 23
Retriever - Golden 22
Boxer (German Boxer) 22
Pit Bull 21
Terrier - Boston 16
Domestic (unspecified) 13

Associated Drugs

Tigilanol Tiglate 133
Carprofen 116
Cefovecin 67
Maropitant Citrate 55
Prednisone 38
Meloxicam 34
Gabapentin 33
Famotidine 32
Selamectin 31
Buprenorphine 28
Butorphanol 27
Anesthetic 26
Enrofloxacin 24
Diphenhydramine 22
Milbemycin Oxime + Spinosad 20
Oclacitinib Maleate 20
Melarsomine Dihydrochloride 19
Ceftiofur Crystalline Free Acid 19
Propofol 17
Moxidectin 17

Skin slough Reaction Insights

695 reports name Skin slough; 90 recorded a death outcome (12.9% of reported events, not a population-level mortality rate). VeDDRA code: 943.

By species: Dog (522 reports), Cat (91 reports), Horse (59 reports). By breed: Domestic Shorthair (53), Retriever - Labrador (47), Dog (unknown) (36).

Most co-reported drugs: Tigilanol Tiglate (133 reports), Carprofen (116 reports), Cefovecin (67 reports), Maropitant Citrate (55 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.