Reaction profile

The FDA adverse-event record for unclassifiable adverse event

2,802 FDA adverse-event reports reference unclassifiable adverse event (VeDDRA 2190). See the species, breeds, and drugs most associated with it below.

2,802
reports citing this reaction
7.9%
death-coded share
Human
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
2,802
Total Reports
220
Deaths
7.9%
Death Rate

Species Most Affected

Human 1,683
Dog 708
Cat 207
Cattle 91
Unknown 63
Pig 20
Horse 13
Other 3
Sheep 3
Turkey 2

Breeds Most Affected

Unknown 1,771
Dog (unknown) 262
Cat (unknown) 100
Domestic Shorthair 49
Retriever - Labrador 40
Crossbred Canine/dog 34
Shepherd Dog - German 22
Cattle (other) 19
Crossbred Bovine/Cattle 19
Cattle (unknown) 17

Associated Drugs

Selamectin 363
Ivermectin 111
Milbemycin Oxime + Spinosad 107
Spinosad 97
Mercaptobenzothiazole 97
Tilmicosin Phosphate 95
Tulathromycin 86
Imidacloprid, Moxidectin 66
Milbemycin Oxime + Praziquantel 64
Buprenorphine 62
Meloxicam 59
Moxidectin 55
Ceftiofur 52
Fluralaner Chew Tablets 51
Monensin Sodium 50
Cyclosporin Ointment 48
Enrofloxacin 46
Carprofen 45
Doramectin 44
Pyrantel Pamoate 44

Unclassifiable adverse event Reaction Insights

2,802 reports name Unclassifiable adverse event; 220 recorded a death outcome (7.9% of reported events, not a population-level mortality rate). VeDDRA code: 2190.

By species: Human (1,683 reports), Dog (708 reports), Cat (207 reports). By breed: Unknown (1,771), Dog (unknown) (262), Cat (unknown) (100).

Most co-reported drugs: Selamectin (363 reports), Ivermectin (111 reports), Milbemycin Oxime + Spinosad (107 reports), Spinosad (97 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.