Reaction profile

The FDA adverse-event record for protrusion membrana nictitans

129 FDA adverse-event reports reference protrusion membrana nictitans (VeDDRA 448). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1267 of 2,481
by report volume (all reactions)
129
reports citing this reaction
10.1%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Protrusion membrana nictitans has 129 reports now versus 128 in that prior snapshot: 1 more (0.8%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Protrusion membrana nictitans changes

FDA AER · VeDDRA plate

Code 448 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 129 reports
  • DEATH-ELEV 10.1%
  • MID-PACK #1267/2481
  • PHOTO-FINISH Elevated SAP
  • SPECIES-CAT Cat · 65
  • DRUG-LEAD Milbemycin Oxime… · 20
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated SAP (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Protrusion membrana nictitans

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Elevated SAP · near129Oral swelling · near129Protrusion membrana n… · thi…129Suspect counterfeit p… · near129Chemosis · near128Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Protrusion membrana nictitans

What the FDA AER plate says about Protrusion membrana nictitans

Signature read: death-coded share at 10.1% is the most distinctive outcome stamp on Protrusion membrana nictitans. Report volume sits in the middle third of the reaction corpus. 13 of 129 reports were death-coded (10.1% of named reports, not a population mortality rate). Nearest volume peer: Elevated SAP (±0 reports). Lead species Cat (65). Lead co-reported drug Milbemycin Oxime + Spinosad (20).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 65
Dog 62
Horse 2

Breeds Most Affected

Domestic Shorthair 39
Boxer (German Boxer) 6
Domestic Longhair 6
Retriever - Golden 5
Cat (unknown) 4
Hound - Basset 4
Terrier - Bull - American Pit 4
Domestic Mediumhair 4
Beagle 3
Bulldog 3

Associated Drugs

Milbemycin Oxime + Spinosad 20
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 20
Maropitant Citrate 9
Oclacitinib Maleate 9
Ear Cleaner 9
Selamectin 5
Carprofen 5
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 5
Florfenicol, Terbinafine, Betamethasone Acetate 5
Imidacloprid + Moxidectin 4
Cefovecin Sodium 4
Mirtazapine 4
Spinosad 3
Afoxolaner 3
Pimobendan 3
Fluids 3
Prednisolone 3
Famotidine 3
Buprenorphine 3
Gabapentin 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Protrusion membrana nictitans, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (129 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Protrusion membrana nictitans (#1267 of 2,481 by report volume); death-coded 10.1%. PlainBreed reaction plate · death-coded share stamp 10.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →