Reaction profile

The FDA adverse-event record for protrusion membrana nictitans

125 FDA adverse-event reports reference protrusion membrana nictitans (VeDDRA 448). See the species, breeds, and drugs most associated with it below.

125
reports citing this reaction
9.6%
death-coded share
Cat
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
125
Total Reports
12
Deaths
9.6%
Death Rate

Species Most Affected

Cat 63
Dog 60
Horse 2

Breeds Most Affected

Domestic Shorthair 37
Boxer (German Boxer) 6
Domestic Longhair 6
Retriever - Golden 5
Cat (unknown) 4
Hound - Basset 4
Domestic Mediumhair 4
Beagle 3
Bulldog 3
Retriever - Labrador 3

Associated Drugs

Milbemycin Oxime + Spinosad 20
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 20
Maropitant Citrate 9
Ear Cleaner 9
Oclacitinib Maleate 7
Selamectin 5
Carprofen 5
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 5
Florfenicol, Terbinafine, Betamethasone Acetate 5
Imidacloprid + Moxidectin 4
Cefovecin Sodium 4
Mirtazapine 4
Spinosad 3
Afoxolaner 3
Pimobendan 3
Fluids 3
Prednisolone 3
Famotidine 3
Buprenorphine 3
Gabapentin 3

Protrusion membrana nictitans Reaction Insights

125 reports name Protrusion membrana nictitans; 12 recorded a death outcome (9.6% of reported events, not a population-level mortality rate). VeDDRA code: 448.

By species: Cat (63 reports), Dog (60 reports), Horse (2 reports). By breed: Domestic Shorthair (37), Boxer (German Boxer) (6), Domestic Longhair (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (20 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (20 reports), Maropitant Citrate (9 reports), Ear Cleaner (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.