Reaction profile

The FDA adverse-event record for abnormal breathing

2,324 FDA adverse-event reports reference abnormal breathing (VeDDRA 837). See the species, breeds, and drugs most associated with it below.

2,324
reports citing this reaction
25.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,324
Total Reports
588
Deaths
25.3%
Death Rate

Species Most Affected

Dog 1,828
Cat 416
Horse 29
Cattle 19
Human 17
Pig 4
Mouse 3
Rabbit 3
Goat 2
Fish 1

Breeds Most Affected

Domestic Shorthair 223
Retriever - Labrador 159
Chihuahua 115
Crossbred Canine/dog 101
Terrier - Yorkshire 77
Retriever - Golden 66
Shih Tzu 62
Boxer (German Boxer) 62
Dog (unknown) 57
Shepherd Dog - German 55

Associated Drugs

Milbemycin Oxime + Spinosad 483
Spinosad 144
Maropitant Citrate 114
Moxidectin 108
Carprofen 104
Nitenpyram 99
Selamectin 86
Afoxolaner 85
Prednisone 83
Cefovecin 83
Oclacitinib Maleate 79
Bedinvetmab 71
Fluralaner Chew Tablets 67
Milbemycin Oxime + Praziquantel 67
Trilostane 61
Gabapentin 60
Buprenorphine 55
Pyrantel Pamoate;Sarolaner 53
Sarolaner 48
Meloxicam 47

Abnormal breathing Reaction Insights

2,324 reports name Abnormal breathing; 588 recorded a death outcome (25.3% of reported events, not a population-level mortality rate). VeDDRA code: 837.

By species: Dog (1,828 reports), Cat (416 reports), Horse (29 reports). By breed: Domestic Shorthair (223), Retriever - Labrador (159), Chihuahua (115).

Most co-reported drugs: Milbemycin Oxime + Spinosad (483 reports), Spinosad (144 reports), Maropitant Citrate (114 reports), Moxidectin (108 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.