Reaction profile

The FDA adverse-event record for abnormal breathing

2,381 FDA reports name abnormal breathing, a high-volume reaction in the CVM extract (VeDDRA 837). Plate stamps and neighbourhood peers follow.

#196 of 2,481
by report volume (all reactions)
2,381
reports citing this reaction
25.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal breathing has 2,381 reports now versus 2,352 in that prior snapshot: 29 more (1.2%).

Report change
+29
Death-coded reports
+9
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal breathing changes

FDA AER · VeDDRA plate

Code 837 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,381 reports
  • DEATH-HOT 25.6%
  • TOP-DECILE #196/2481
  • PHOTO-FINISH Neutropenia
  • SPECIES-DOG Dog · 1,869
  • DRUG-LEAD Milbemycin Oxime… · 484
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Neutropenia (±7 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Abnormal breathing

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated temperature · near2434Abnormal breathing · this re…2381Neutropenia · near2374Dispenser, Abnormal · near2350Rash · near2339Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal breathing

Abnormal breathing: high death-coded share in the FDA AER plate

Signature read: 609 death-coded reports is a heavy tail count for Abnormal breathing in the CVM extract. Report volume is upper-third scale: 2,381 named reports in the openFDA extract. Death-coded share is upper-third: 609 of 2,381 reports (25.6% of named reports). Nearest volume peer: Neutropenia (±7 reports). Lead species Dog (1,869). Lead co-reported drug Milbemycin Oxime + Spinosad (484).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,869
Cat 430
Horse 30
Cattle 19
Human 17
Pig 4
Mouse 3
Rabbit 3
Goat 2
Fish 1

Breeds Most Affected

Domestic Shorthair 232
Retriever - Labrador 165
Chihuahua 118
Crossbred Canine/dog 102
Terrier - Yorkshire 80
Retriever - Golden 68
Shih Tzu 63
Boxer (German Boxer) 62
Dog (unknown) 57
Shepherd Dog - German 57

Associated Drugs

Milbemycin Oxime + Spinosad 484
Spinosad 144
Maropitant Citrate 114
Moxidectin 111
Carprofen 109
Nitenpyram 102
Selamectin 86
Afoxolaner 86
Prednisone 85
Cefovecin 83
Bedinvetmab 81
Oclacitinib Maleate 80
Fluralaner Chew Tablets 67
Milbemycin Oxime + Praziquantel 67
Gabapentin 66
Trilostane 62
Pyrantel Pamoate;Sarolaner 59
Buprenorphine 56
Doxycycline 49
Sarolaner 48

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal breathing, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,381 here).

Similar death-coded share

Nearest other reactions by death-coded share (25.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal breathing (#196 of 2,481 by report volume); death-coded 25.6%. PlainBreed reaction plate · death-coded report count stamp 609 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →