Reaction profile

The FDA adverse-event record for necrosis nos

78 FDA adverse-event reports reference necrosis nos (VeDDRA 2889). See the species, breeds, and drugs most associated with it below.

78
reports citing this reaction
42.3%
death-coded share
Dog
most-affected species
Gabapentin
most-associated drug
Verify with FDA CVM →
78
Total Reports
33
Deaths
42.3%
Death Rate

Species Most Affected

Dog 63
Cat 12
Cattle 2
Horse 1

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 7
Pit Bull 5
Dog (unknown) 4
Crossbred Canine/dog 4
Beagle 4
Shih Tzu 3
Maltese 3
Terrier - Yorkshire 3
Chihuahua 2

Associated Drugs

Gabapentin 22
Tigilanol Tiglate 20
Maropitant Citrate 17
Prednisone 12
Diphenhydramine 12
Bedinvetmab 12
Famotidine 11
Buprenorphine 10
Midazolam 8
Propofol 7
Carprofen 7
Dexmedetomidine 6
Butorphanol Tartrate 6
Bupivacaine 5
Anesthetic (Unknown) 5
Butorphanol 5
Tramadol 5
Dexmedetomidine Hydrochloride 5
Trazodone 5
Robenacoxib 4

Necrosis NOS Reaction Insights

78 reports name Necrosis NOS; 33 recorded a death outcome (42.3% of reported events, not a population-level mortality rate). VeDDRA code: 2889.

By species: Dog (63 reports), Cat (12 reports), Cattle (2 reports). By breed: Domestic Shorthair (10), Retriever - Labrador (7), Pit Bull (5).

Most co-reported drugs: Gabapentin (22 reports), Tigilanol Tiglate (20 reports), Maropitant Citrate (17 reports), Prednisone (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.