Reaction profile

The FDA adverse-event record for red blood cells(rbc) nucleated

88 FDA adverse-event reports reference red blood cells(rbc) nucleated (VeDDRA 99336). See the species, breeds, and drugs most associated with it below.

88
reports citing this reaction
28.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
88
Total Reports
25
Deaths
28.4%
Death Rate

Species Most Affected

Dog 80
Cat 7
Horse 1

Breeds Most Affected

Crossbred Canine/dog 9
Retriever - Labrador 9
Domestic Shorthair 6
Chihuahua 4
Maltese 3
Terrier - West Highland White 3
Spaniel - Cocker American 3
Spitz - German Pomeranian 3
Schnauzer - Miniature 3
Retriever - Golden 3

Associated Drugs

Carprofen 8
Moxidectin 7
Spinosad 6
Prednisone 6
Ivermectin + Pyrantel As Pamoate Salt 6
Cyclosporine 5
Milbemycin Oxime + Spinosad 5
Oclacitinib Maleate 5
Meloxicam 4
Enrofloxacin 4
Grapiprant 4
Pyrantel Pamoate;Sarolaner 4
Deracoxib 3
Trilostane 3
Cyclosporine A 3
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 3
Maropitant Citrate 3
Cefovecin Sodium 2
Glycosaminoglycan Polysulfate 2
Selamectin 2

RED BLOOD CELLS(RBC) NUCLEATED Reaction Insights

88 reports name RED BLOOD CELLS(RBC) NUCLEATED; 25 recorded a death outcome (28.4% of reported events, not a population-level mortality rate). VeDDRA code: 99336.

By species: Dog (80 reports), Cat (7 reports), Horse (1 reports). By breed: Crossbred Canine/dog (9), Retriever - Labrador (9), Domestic Shorthair (6).

Most co-reported drugs: Carprofen (8 reports), Moxidectin (7 reports), Spinosad (6 reports), Prednisone (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.