Reaction profile

The FDA adverse-event record for lymphopenia

2,716 FDA reports name lymphopenia, a high-volume reaction in the CVM extract (VeDDRA 166). Plate stamps and neighbourhood peers follow.

#172 of 2,481
by report volume (all reactions)
2,716
reports citing this reaction
22.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lymphopenia has 2,716 reports now versus 2,625 in that prior snapshot: 91 more (3.5%).

Report change
+91
Death-coded reports
+12
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lymphopenia changes

FDA AER · VeDDRA plate

Code 166 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,716 reports
  • DEATH-HOT 22.9%
  • TOP-DECILE #172/2481
  • PHOTO-FINISH Urticaria
  • SPECIES-DOG Dog · 2,169
  • DRUG-LEAD Oclacitinib Malea… · 427
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Urticaria (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lymphopenia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hypothermia · near2724Urticaria · near2718Lymphopenia · this reaction2716Pancreatitis · near2707Elevated serum alkali… · near2701Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lymphopenia

What the FDA AER plate says about Lymphopenia

Signature read: 622 death-coded reports is a heavy tail count for Lymphopenia in the CVM extract. Report volume is upper-third scale: 2,716 named reports in the openFDA extract. 622 of 2,716 reports were death-coded (22.9% of named reports, not a population mortality rate). Nearest volume peer: Urticaria (±2 reports). Lead species Dog (2,169). Lead co-reported drug Oclacitinib Maleate (427).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Oclacitinib Maleate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,169
Cat 484
Horse 59
Cattle 2
Other Birds 1
Other Canids 1

Breeds Most Affected

Domestic Shorthair 287
Retriever - Labrador 265
Crossbred Canine/dog 142
Retriever - Golden 113
Shepherd Dog - German 75
Boxer (German Boxer) 68
Shih Tzu 66
Chihuahua 62
Shepherd Dog - Australian 61
Bulldog - French 57

Associated Drugs

Oclacitinib Maleate 427
Maropitant Citrate 296
Carprofen 232
Milbemycin Oxime + Spinosad 189
Gabapentin 165
Trilostane 163
Afoxolaner 162
Prednisone 145
Enrofloxacin 120
Bedinvetmab 114
Ilunocitinib 114
Cefovecin 109
Fluralaner Chew Tablets 101
Moxidectin 96
Metronidazole 93
Spinosad 89
Buprenorphine 84
Famotidine 82
Ivermectin + Pyrantel As Pamoate Salt 81
Meloxicam 79

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lymphopenia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,716 here).

Similar death-coded share

Nearest other reactions by death-coded share (22.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lymphopenia (#172 of 2,481 by report volume); death-coded 22.9%. PlainBreed reaction plate · death-coded report count stamp 622 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →