Reaction profile

The FDA adverse-event record for lymphopenia

2,482 FDA adverse-event reports reference lymphopenia (VeDDRA 166). See the species, breeds, and drugs most associated with it below.

2,482
reports citing this reaction
23.2%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
2,482
Total Reports
577
Deaths
23.2%
Death Rate

Species Most Affected

Dog 1,980
Cat 443
Horse 55
Cattle 2
Other Birds 1
Other Canids 1

Breeds Most Affected

Domestic Shorthair 259
Retriever - Labrador 239
Crossbred Canine/dog 125
Retriever - Golden 100
Boxer (German Boxer) 66
Shih Tzu 64
Shepherd Dog - German 62
Chihuahua 56
Shepherd Dog - Australian 53
Beagle 50

Associated Drugs

Oclacitinib Maleate 380
Maropitant Citrate 241
Carprofen 215
Milbemycin Oxime + Spinosad 188
Trilostane 154
Afoxolaner 140
Gabapentin 136
Prednisone 123
Enrofloxacin 104
Cefovecin 103
Fluralaner Chew Tablets 101
Bedinvetmab 97
Spinosad 89
Moxidectin 87
Ivermectin + Pyrantel As Pamoate Salt 77
Meloxicam 76
Famotidine 75
Metronidazole 74
Buprenorphine 68
Cyclosporine 66

Lymphopenia Reaction Insights

2,482 reports name Lymphopenia; 577 recorded a death outcome (23.2% of reported events, not a population-level mortality rate). VeDDRA code: 166.

By species: Dog (1,980 reports), Cat (443 reports), Horse (55 reports). By breed: Domestic Shorthair (259), Retriever - Labrador (239), Crossbred Canine/dog (125).

Most co-reported drugs: Oclacitinib Maleate (380 reports), Maropitant Citrate (241 reports), Carprofen (215 reports), Milbemycin Oxime + Spinosad (188 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.