Reaction profile

The FDA adverse-event record for hypothermia

2,624 FDA adverse-event reports reference hypothermia (VeDDRA 1015). See the species, breeds, and drugs most associated with it below.

2,624
reports citing this reaction
41.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
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2,624
Total Reports
1,080
Deaths
41.2%
Death Rate

Species Most Affected

Dog 1,433
Cat 1,133
Cattle 17
Horse 13
Rabbit 5
Human 4
Guinea Pig 3
Ferret 3
Goat 2
Chinchilla 2

Breeds Most Affected

Domestic Shorthair 605
Chihuahua 143
Domestic (unspecified) 141
Crossbred Canine/dog 96
Retriever - Labrador 95
Terrier - Yorkshire 94
Domestic Longhair 68
Cat (unknown) 67
Domestic Mediumhair 67
Dachshund (unspecified) 60

Associated Drugs

Maropitant Citrate 309
Buprenorphine 258
Cefovecin 218
Isoflurane 210
Carprofen 192
Meloxicam 138
Dexmedetomidine Hydrochloride 132
Moxidectin 131
Milbemycin Oxime + Spinosad 126
Selamectin 123
Butorphanol 114
Ketamine 113
Propofol 111
Fentanyl 90
Cefovecin Sodium 89
Dexamethasone 83
Robenacoxib 82
Spinosad 81
Melarsomine Dihydrochloride 74
Enrofloxacin 74

Hypothermia Reaction Insights

2,624 reports name Hypothermia; 1,080 recorded a death outcome (41.2% of reported events, not a population-level mortality rate). VeDDRA code: 1015.

By species: Dog (1,433 reports), Cat (1,133 reports), Cattle (17 reports). By breed: Domestic Shorthair (605), Chihuahua (143), Domestic (unspecified) (141).

Most co-reported drugs: Maropitant Citrate (309 reports), Buprenorphine (258 reports), Cefovecin (218 reports), Isoflurane (210 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.