Reaction profile

The FDA adverse-event record for urticaria

2,700 FDA adverse-event reports reference urticaria (VeDDRA 521). See the species, breeds, and drugs most associated with it below.

2,700
reports citing this reaction
1.2%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
2,700
Total Reports
33
Deaths
1.2%
Death Rate

Species Most Affected

Dog 2,410
Horse 140
Human 89
Cat 40
Cattle 14
Pig 2
Donkey 2
Sheep 1
Unknown 1
Other Equids 1

Breeds Most Affected

Boxer (German Boxer) 270
Retriever - Labrador 233
Crossbred Canine/dog 196
Terrier - Bull - American Pit 181
Chihuahua 131
Unknown 100
Dachshund (unspecified) 99
Pit Bull 95
Terrier - Boston 71
Bulldog 68

Associated Drugs

Moxidectin 903
Spinosad 143
Selamectin 123
Milbemycin Oxime + Spinosad 122
Rabies Virus, Kv 112
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 106
Imidacloprid + Moxidectin 105
Maropitant Citrate 96
Diphenhydramine Hcl 95
Oclacitinib Maleate 73
Carprofen 66
Melarsomine Dihydrochloride 66
Afoxolaner 62
Dexamethasone 54
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 54
Pyrantel Pamoate 52
Prednisone 49
Anti-Il31 Mab Mcs Lot #1283563 45
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 44
Bordetella Bronchiseptica, Strain 78-9159, Kb 42

Urticaria Reaction Insights

2,700 reports name Urticaria; 33 recorded a death outcome (1.2% of reported events, not a population-level mortality rate). VeDDRA code: 521.

By species: Dog (2,410 reports), Horse (140 reports), Human (89 reports). By breed: Boxer (German Boxer) (270), Retriever - Labrador (233), Crossbred Canine/dog (196).

Most co-reported drugs: Moxidectin (903 reports), Spinosad (143 reports), Selamectin (123 reports), Milbemycin Oxime + Spinosad (122 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.