Reaction profile

The FDA adverse-event record for rectal bleeding

529 FDA reports name rectal bleeding, a high-volume reaction in the CVM extract (VeDDRA 272). Plate stamps and neighbourhood peers follow.

#625 of 2,481
by report volume (all reactions)
529
reports citing this reaction
32.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rectal bleeding has 529 reports now versus 525 in that prior snapshot: 4 more (0.8%).

Report change
+4
Death-coded reports
+2
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rectal bleeding changes

FDA AER · VeDDRA plate

Code 272 VOL-MID

VOL-MID · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 529 reports
  • DEATH-HOT 32.9%
  • MID-PACK #625/2481
  • PHOTO-FINISH Oedema NOS (see other…
  • SPECIES-DOG Dog · 473
  • DRUG-LEAD Carprofen · 65
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Oedema NOS (see other SOCs for specific oedemas) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Rectal bleeding

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site crust · near530Loss of consciousness · near530Oedema NOS (see other… · near529Rectal bleeding · this react…529Lot # and /or Expirat… · near528Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Rectal bleeding

Rectal bleeding: high death-coded share in the FDA AER plate

Signature read: 174 death-coded reports is a heavy tail count for Rectal bleeding in the CVM extract. Report volume is upper-third scale: 529 named reports in the openFDA extract. Death-coded share is upper-third: 174 of 529 reports (32.9% of named reports). Nearest volume peer: Oedema NOS (see other SOCs for specific oedemas) (±0 reports). Lead species Dog (473). Lead co-reported drug Carprofen (65).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 473
Cat 48
Horse 4
Cattle 2
Human 1
Chicken 1

Breeds Most Affected

Crossbred Canine/dog 43
Retriever - Labrador 36
Chihuahua 29
Terrier - Yorkshire 23
Domestic Shorthair 21
Dog (unknown) 17
Dachshund (unspecified) 16
Shih Tzu 16
Retriever - Golden 13
Siberian Husky 11

Associated Drugs

Carprofen 65
Milbemycin Oxime + Spinosad 55
Maropitant Citrate 43
Moxidectin 35
Afoxolaner 27
Grapiprant 20
Firocoxib 17
Spinosad 17
Ivermectin + Pyrantel As Pamoate Salt 17
Meloxicam 15
Selamectin 15
Famotidine 15
Oclacitinib Maleate 15
Gabapentin 15
Bedinvetmab 15
Dexamethasone 13
Metronidazole 13
Pyrantel Pamoate;Sarolaner 13
Cefovecin 12
Melarsomine Dihydrochloride 11

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Rectal bleeding, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rectal bleeding (#625 of 2,481 by report volume); death-coded 32.9%. PlainBreed reaction plate · death-coded report count stamp 174 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →