Reaction profile

The FDA adverse-event record for rectal bleeding

510 FDA adverse-event reports reference rectal bleeding (VeDDRA 272). See the species, breeds, and drugs most associated with it below.

510
reports citing this reaction
32.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
510
Total Reports
168
Deaths
32.9%
Death Rate

Species Most Affected

Dog 454
Cat 48
Horse 4
Cattle 2
Human 1
Chicken 1

Breeds Most Affected

Crossbred Canine/dog 42
Retriever - Labrador 35
Chihuahua 29
Terrier - Yorkshire 23
Domestic Shorthair 21
Dachshund (unspecified) 16
Shih Tzu 16
Dog (unknown) 14
Siberian Husky 11
Retriever - Golden 11

Associated Drugs

Carprofen 63
Milbemycin Oxime + Spinosad 54
Maropitant Citrate 43
Moxidectin 35
Afoxolaner 27
Grapiprant 20
Firocoxib 17
Spinosad 17
Selamectin 15
Meloxicam 15
Famotidine 15
Ivermectin + Pyrantel As Pamoate Salt 15
Bedinvetmab 15
Oclacitinib Maleate 14
Dexamethasone 13
Metronidazole 13
Gabapentin 13
Cefovecin 12
Pyrantel Pamoate;Sarolaner 12
Melarsomine Dihydrochloride 11

Rectal bleeding Reaction Insights

510 reports name Rectal bleeding; 168 recorded a death outcome (32.9% of reported events, not a population-level mortality rate). VeDDRA code: 272.

By species: Dog (454 reports), Cat (48 reports), Horse (4 reports). By breed: Crossbred Canine/dog (42), Retriever - Labrador (35), Chihuahua (29).

Most co-reported drugs: Carprofen (63 reports), Milbemycin Oxime + Spinosad (54 reports), Maropitant Citrate (43 reports), Moxidectin (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.