Reaction profile

The FDA adverse-event record for loss of condition score

154 FDA adverse-event reports reference loss of condition score (VeDDRA 1045). See the species, breeds, and drugs most associated with it below.

154
reports citing this reaction
34.4%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
154
Total Reports
53
Deaths
34.4%
Death Rate

Species Most Affected

Dog 83
Cat 38
Cattle 23
Pig 5
Horse 3
Turkey 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 24
Retriever - Labrador 10
Crossbred Canine/dog 9
Holstein-Friesian also known as Holstein 8
Cattle (unknown) 5
Terrier - Yorkshire 4
Domestic Longhair 4
Shepherd Dog - German 4
Maltese 4
Aberdeen Angus 4

Associated Drugs

Trilostane 53
Bexagliflozin 21
Milbemycin Oxime + Spinosad 13
Enrofloxacin 9
Gabapentin 8
Prednisone 7
Carprofen 7
Grapiprant 6
Amlodipine 6
Maropitant Citrate 6
Monensin Sodium 5
Ractopamine Hydrochloride 5
Spinosad 5
Moxidectin 5
Fluralaner Chew Tablets 5
Rabies Vaccine 5
Midazolam 5
Thiamazole 5
Insulin 4
Milbemycin Oxime + Praziquantel 4

Loss of condition score Reaction Insights

154 reports name Loss of condition score; 53 recorded a death outcome (34.4% of reported events, not a population-level mortality rate). VeDDRA code: 1045.

By species: Dog (83 reports), Cat (38 reports), Cattle (23 reports). By breed: Domestic Shorthair (24), Retriever - Labrador (10), Crossbred Canine/dog (9).

Most co-reported drugs: Trilostane (53 reports), Bexagliflozin (21 reports), Milbemycin Oxime + Spinosad (13 reports), Enrofloxacin (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.