Reaction profile

The FDA adverse-event record for cranial nerve disorder

97 FDA adverse-event reports reference cranial nerve disorder (VeDDRA 1147). See the species, breeds, and drugs most associated with it below.

97
reports citing this reaction
34.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
97
Total Reports
33
Deaths
34.0%
Death Rate

Species Most Affected

Dog 76
Cat 14
Horse 6
Cattle 1

Breeds Most Affected

Crossbred Canine/dog 9
Domestic Shorthair 9
Boxer (German Boxer) 7
Chihuahua 5
Maltese 5
Terrier - Yorkshire 4
Pug 3
Retriever - Labrador 3
Bulldog 3
Pit Bull 3

Associated Drugs

Milbemycin Oxime + Spinosad 15
Moxidectin 10
Prednisone 9
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 9
Gabapentin 8
Bedinvetmab 8
Spinosad 6
Maropitant Citrate 6
Fluid Therapy 6
Fluralaner Chew Tablets 5
Enrofloxacin 5
Carprofen 5
Ceftiofur Crystalline Free Acid 4
Butorphanol 4
Phenobarbital 4
Oclacitinib Maleate 4
Doxycycline 4
Buprenorphine 4
Diphenhydramine Injection 4
Cyclosporine 4

Cranial nerve disorder Reaction Insights

97 reports name Cranial nerve disorder; 33 recorded a death outcome (34.0% of reported events, not a population-level mortality rate). VeDDRA code: 1147.

By species: Dog (76 reports), Cat (14 reports), Horse (6 reports). By breed: Crossbred Canine/dog (9), Domestic Shorthair (9), Boxer (German Boxer) (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (15 reports), Moxidectin (10 reports), Prednisone (9 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.