Ecchymosis

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VeDDRA Code: 2038

417 adverse event reports referencing this reaction

417
Total Reports
140
Deaths
3360.0%
Death Rate

Species Most Affected

Dog 350
Cat 34
Human 29
Cattle 2
Horse 1
Other Birds 1

Breeds Most Affected

Crossbred Canine/dog 35
Retriever - Labrador 31
Unknown 30
Chihuahua 18
Maltese 17
Retriever - Golden 15
Domestic (unspecified) 13
Poodle (unspecified) 12
Dachshund (unspecified) 12
Pit Bull 10

Associated Drugs

Carprofen 73
Maropitant Citrate 32
Meloxicam 31
Moxidectin 26
Prednisone 23
Doxycycline 20
Milbemycin Oxime + Spinosad 19
Cefovecin 18
Bedinvetmab 16
Deracoxib 15
Cefpodoxime Proxetil 15
Oclacitinib Maleate 15
Cefovecin Sodium 14
Dexamethasone 13
Metronidazole 13
Enrofloxacin 12
Trilostane 11
Famotidine 11
Diphenhydramine 11
Afoxolaner 11

Data Summary

Metric Value
Total reports referencing reaction 417
Reports with fatal outcome 140
Case-fatality rate (reported events) 3360.0%
Species observed 6
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2038.

Ecchymosis Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 417 adverse event reports that reference Ecchymosis as a reaction term, including 140 reports with a death outcome — a 3360.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2038, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Ecchymosis appears most frequently in reports for Dog (350 reports), Cat (34 reports), Human (29 reports) — with Dog dominating at 350 entries. Within those species, the breeds most often named alongside this reaction are Crossbred Canine/dog (35), Retriever - Labrador (31), Unknown (30). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Ecchymosis are Carprofen (73 reports), Maropitant Citrate (32 reports), Meloxicam (31 reports), Moxidectin (26 reports), with Carprofen appearing alongside this reaction in 73 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial