Reaction profile

The FDA adverse-event record for corneal oedema

164 FDA adverse-event reports reference corneal oedema (VeDDRA 413). See the species, breeds, and drugs most associated with it below.

164
reports citing this reaction
9.8%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
164
Total Reports
16
Deaths
9.8%
Death Rate

Species Most Affected

Dog 131
Cat 19
Cattle 8
Human 3
Horse 3

Breeds Most Affected

Shih Tzu 20
Retriever - Labrador 9
Crossbred Canine/dog 8
Domestic Shorthair 8
Terrier - Yorkshire 7
Spaniel - Cocker American 5
Schnauzer - Miniature 5
Cat (unknown) 4
Collie - Border 4
Deutsche Dogge, Great Dane 4

Associated Drugs

Maropitant Citrate 18
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 18
Oclacitinib Maleate 15
Prednisone 11
Isoflurane 10
Carprofen 10
Enrofloxacin 10
Afoxolaner 9
Fluids 9
Cyclosporine 8
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 8
Fluralaner Chew Tablets 8
Eye Lubricant 8
Ofloxacin 7
Spinosad 6
Moxidectin 6
Diphenhydramine 6
Tramadol 6
Gabapentin 6
Buprenorphine 6

Corneal oedema Reaction Insights

164 reports name Corneal oedema; 16 recorded a death outcome (9.8% of reported events, not a population-level mortality rate). VeDDRA code: 413.

By species: Dog (131 reports), Cat (19 reports), Cattle (8 reports). By breed: Shih Tzu (20), Retriever - Labrador (9), Crossbred Canine/dog (8).

Most co-reported drugs: Maropitant Citrate (18 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (18 reports), Oclacitinib Maleate (15 reports), Prednisone (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.