Reaction profile

The FDA adverse-event record for cervical ventroflexion

69 FDA adverse-event reports reference cervical ventroflexion (VeDDRA 2123). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
33.3%
death-coded share
Cat
most-affected species
Eprinomectin + Esafoxolaner + Praziquantel
most-associated drug
Verify with FDA CVM →
69
Total Reports
23
Deaths
33.3%
Death Rate

Species Most Affected

Cat 58
Dog 11

Breeds Most Affected

Domestic Shorthair 31
Domestic Longhair 4
Domestic (unspecified) 3
Domestic Mediumhair 3
Siamese 3
Cat (other) 3
Cat (unknown) 3
Boxer (German Boxer) 2
Russian 2
Abyssinian cat 2

Associated Drugs

Eprinomectin + Esafoxolaner + Praziquantel 7
Cefovecin 6
Maropitant Citrate 6
Buprenorphine 6
Fluralaner Spot-On Solution 6
Spinosad 5
Selamectin;Sarolaner 4
Frunevetmab 4
Selamectin 3
Methylprednisolone Acetate 3
Robenacoxib 3
Butorphanol 3
Ketamine 3
Thiamazole 3
Mirtazapine 3
Potassium Chloride 3
Bexagliflozin 3
Cefovecin Sodium 2
Carprofen 2
Gabapentin 2

Cervical ventroflexion Reaction Insights

69 reports name Cervical ventroflexion; 23 recorded a death outcome (33.3% of reported events, not a population-level mortality rate). VeDDRA code: 2123.

By species: Cat (58 reports), Dog (11 reports). By breed: Domestic Shorthair (31), Domestic Longhair (4), Domestic (unspecified) (3).

Most co-reported drugs: Eprinomectin + Esafoxolaner + Praziquantel (7 reports), Cefovecin (6 reports), Maropitant Citrate (6 reports), Buprenorphine (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.