Reaction profile

The FDA adverse-event record for chattering of teeth

373 FDA adverse-event reports reference chattering of teeth (VeDDRA 1072). See the species, breeds, and drugs most associated with it below.

373
reports citing this reaction
5.1%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
373
Total Reports
19
Deaths
5.1%
Death Rate

Species Most Affected

Dog 355
Cat 16
Rabbit 1
Horse 1

Breeds Most Affected

Retriever - Labrador 59
Crossbred Canine/dog 38
Retriever - Golden 24
Chihuahua 12
Domestic Shorthair 12
Terrier - Yorkshire 12
Terrier - Jack Russell 10
Dog (unknown) 10
Terrier - Bull - American Pit 8
Boxer (German Boxer) 8

Associated Drugs

Afoxolaner 47
Pyrantel Pamoate;Sarolaner 43
Sarolaner 32
Milbemycin Oxime + Spinosad 27
Fluralaner Chew Tablets 25
Bedinvetmab 25
Ivermectin + Pyrantel As Pamoate Salt 20
Fluralaner 13.64% 12-Week Chew 18
Trilostane 17
Milbemycin Oxime + Praziquantel 17
Maropitant Citrate 15
Gabapentin 15
Carprofen 13
Spinosad 12
Prednisone 12
Oclacitinib Maleate 12
Moxidectin 11
Selamectin 9
Cyclosporine A 8
Lotilaner 8

Chattering of teeth Reaction Insights

373 reports name Chattering of teeth; 19 recorded a death outcome (5.1% of reported events, not a population-level mortality rate). VeDDRA code: 1072.

By species: Dog (355 reports), Cat (16 reports), Rabbit (1 reports). By breed: Retriever - Labrador (59), Crossbred Canine/dog (38), Retriever - Golden (24).

Most co-reported drugs: Afoxolaner (47 reports), Pyrantel Pamoate;Sarolaner (43 reports), Sarolaner (32 reports), Milbemycin Oxime + Spinosad (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.