Reaction profile

The FDA adverse-event record for histiocytoma

249 FDA adverse-event reports reference histiocytoma (VeDDRA 917). See the species, breeds, and drugs most associated with it below.

249
reports citing this reaction
5.6%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
249
Total Reports
14
Deaths
5.6%
Death Rate

Species Most Affected

Dog 246
Pig 2
Cat 1

Breeds Most Affected

Retriever - Labrador 28
Boxer (German Boxer) 24
Terrier - Bull - American Pit 19
Dog (unknown) 14
Bulldog - French 11
Crossbred Canine/dog 11
Beagle 8
Terrier - Yorkshire 7
Retriever - Golden 6
Terrier (unspecified) 6

Associated Drugs

Oclacitinib Maleate 196
Anti-Il31 Mab Mcs Lot #1283563 24
Milbemycin Oxime + Spinosad 19
Cyclosporine A 11
Ketoconazole 9
Prednisolone; Trimeprazine Tartrate 8
Selamectin 8
Cephalexin 8
Milbemycin Oxime + Praziquantel 7
Cefpodoxime 6
Prednisone 6
Ivermectin 6
Immunotherapy 6
Lotilaner 6
Cefovecin 5
Fish Oil 5
Cyclosporine 5
Diphenhydramine Hcl 4
Metronidazole 4
Afoxolaner 4

Histiocytoma Reaction Insights

249 reports name Histiocytoma; 14 recorded a death outcome (5.6% of reported events, not a population-level mortality rate). VeDDRA code: 917.

By species: Dog (246 reports), Pig (2 reports), Cat (1 reports). By breed: Retriever - Labrador (28), Boxer (German Boxer) (24), Terrier - Bull - American Pit (19).

Most co-reported drugs: Oclacitinib Maleate (196 reports), Anti-Il31 Mab Mcs Lot #1283563 (24 reports), Milbemycin Oxime + Spinosad (19 reports), Cyclosporine A (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.