Reaction profile

The FDA adverse-event record for lens opacity

52 FDA adverse-event reports reference lens opacity (VeDDRA 443). See the species, breeds, and drugs most associated with it below.

52
reports citing this reaction
13.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
52
Total Reports
7
Deaths
13.5%
Death Rate

Species Most Affected

Dog 49
Cat 2
Goat 1

Breeds Most Affected

Chihuahua 5
Retriever - Labrador 5
Crossbred Canine/dog 5
Maltese 3
Spitz - German Pomeranian 2
Schnauzer - Miniature 2
Dachshund (unspecified) 2
Beagle 2
Dog (unknown) 2
Dog (other) 1

Associated Drugs

Trilostane 25
Milbemycin Oxime + Spinosad 10
Fluralaner 5
Ivermectin 4
Milbemycin Oxime 4
Lotilaner 4
Recombinant Human Insulin 3
Carprofen 3
Afoxolaner 3
Bordetella Vaccine 3
Tramadol 3
Dorzolamide Hcl & Timolol Maleate 2
Enrofloxacin 2
Loratidine 2
Ivermectin + Pyrantel As Pamoate Salt 2
Sarolaner 2
Leptospirosis Vaccine 2
Rabies Vaccine 2
Ursodiol 2
Moxidectin 2

Lens opacity Reaction Insights

52 reports name Lens opacity; 7 recorded a death outcome (13.5% of reported events, not a population-level mortality rate). VeDDRA code: 443.

By species: Dog (49 reports), Cat (2 reports), Goat (1 reports). By breed: Chihuahua (5), Retriever - Labrador (5), Crossbred Canine/dog (5).

Most co-reported drugs: Trilostane (25 reports), Milbemycin Oxime + Spinosad (10 reports), Fluralaner (5 reports), Ivermectin (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.