Reaction profile

The FDA adverse-event record for labelled drug-drug interaction medication error

622 FDA reports name labelled drug-drug interaction medication error, a high-volume reaction in the CVM extract (VeDDRA 99842). Plate stamps and neighbourhood peers follow.

#561 of 2,481
by report volume (all reactions)
622
reports citing this reaction
13.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Labelled drug-drug interaction medication error has 622 reports now versus 621 in that prior snapshot: 1 more (0.2%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Labelled drug-drug interaction medication error changes

FDA AER · VeDDRA plate

Code 99842 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 622 reports
  • DEATH-ELEV 13.2%
  • UPPER-Q #561/2481
  • PHOTO-FINISH Increased salivation
  • SPECIES-DOG Dog · 564
  • DRUG-LEAD Spinosad · 209
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased salivation (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Labelled drug-drug interaction medication error

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Low blood pressure · near624Increased salivation · near622Labelled drug-drug in… · thi…622Head tilt - neurologi… · near621Cataract · near619Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Labelled drug-drug interaction medication error

What the FDA AER plate says about Labelled drug-drug interaction medication error

Signature read: 82 death-coded reports is a heavy tail count for Labelled drug-drug interaction medication error in the CVM extract. Report volume is upper-third scale: 622 named reports in the openFDA extract. 82 of 622 reports were death-coded (13.2% of named reports, not a population mortality rate). Nearest volume peer: Increased salivation (±0 reports). Lead species Dog (564). Lead co-reported drug Spinosad (209).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 564
Cat 52
Horse 3
Human 2
Pig 1

Breeds Most Affected

Crossbred Canine/dog 88
Retriever - Labrador 75
Shepherd Dog - German 25
Dog (unknown) 21
Bulldog 21
Chihuahua 20
Retriever - Golden 19
Pit Bull 19
Domestic (unspecified) 18
Boxer (German Boxer) 16

Associated Drugs

Spinosad 209
Ivermectin 164
Milbemycin Oxime + Spinosad 114
Cyclosporine 100
Carprofen 54
Firocoxib 31
Meloxicam 23
Deracoxib 17
Dexmedetomidine Hydrochloride 17
Cefovecin Sodium 16
Spinosad, Milbemycin 13
Robenacoxib 13
Cephalexin 9
Grapiprant 8
Prednisone 6
Ketoconazole 5
Ketoprofen 4
Tramadol 4
Maropitant 3
Vaccines (Unknown) 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Labelled drug-drug interaction medication error, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (622 here).

Similar death-coded share

Nearest other reactions by death-coded share (13.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Labelled drug-drug interaction medication error (#561 of 2,481 by report volume); death-coded 13.2%. PlainBreed reaction plate · death-coded report count stamp 82 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →