Reaction profile

The FDA adverse-event record for hyperthyroidism

258 FDA adverse-event reports reference hyperthyroidism (VeDDRA 403). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#920 of 2,481
by report volume (all reactions)
258
reports citing this reaction
13.2%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyperthyroidism has 258 reports now versus 248 in that prior snapshot: 10 more (4.0%).

Report change
+10
Death-coded reports
+0
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyperthyroidism changes

FDA AER · VeDDRA plate

Code 403 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 258 reports
  • DEATH-ELEV 13.2%
  • MID-PACK #920/2481
  • PHOTO-FINISH Apathy
  • SPECIES-CAT Cat · 182
  • DRUG-LEAD Frunevetmab · 34
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Apathy (±1 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Hyperthyroidism

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Hyperventilation · near259Hyperthyroidism · this react…258Apathy · near257Injection site infect… · near257Injection site mucopu… · near257Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyperthyroidism

What the FDA AER plate says about Hyperthyroidism

Signature read: 34 death-coded reports is the most distinctive absolute-outcome stamp on Hyperthyroidism. Report volume sits in the middle third of the reaction corpus. 34 of 258 reports were death-coded (13.2% of named reports, not a population mortality rate). Nearest volume peer: Apathy (±1 reports). Lead species Cat (182). Lead co-reported drug Frunevetmab (34).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Frunevetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 182
Dog 74
Human 2

Breeds Most Affected

Domestic Shorthair 116
Domestic Longhair 15
Retriever - Labrador 12
Domestic Mediumhair 11
Domestic (unspecified) 8
Cat (other) 8
Cat (unknown) 7
Retriever - Golden 5
Bichon Frise 4
Maine Coon 4

Associated Drugs

Frunevetmab 34
Spinosad 29
Methimazole 26
Trilostane 17
Bexagliflozin 15
Imidacloprid + Moxidectin 12
Cefovecin 9
Cyclosporine 9
Fluralaner Spot-On Solution 9
Levothyroxine 8
Selamectin 7
Maropitant Citrate 7
Oclacitinib Maleate 7
Fluralaner/Moxidectin Spot-On 7
Insulin Injectable Vial 6
Nitenpyram 6
Insulin 6
Lotilaner 6
Meloxicam 5
Emodepside + Praziquantel 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hyperthyroidism, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (258 here).

Similar death-coded share

Nearest other reactions by death-coded share (13.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyperthyroidism (#920 of 2,481 by report volume); death-coded 13.2%. PlainBreed reaction plate · death-coded report count stamp 34 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →