Reaction profile

The FDA adverse-event record for hyperthyroidism

239 FDA adverse-event reports reference hyperthyroidism (VeDDRA 403). See the species, breeds, and drugs most associated with it below.

239
reports citing this reaction
14.2%
death-coded share
Cat
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
239
Total Reports
34
Deaths
14.2%
Death Rate

Species Most Affected

Cat 165
Dog 72
Human 2

Breeds Most Affected

Domestic Shorthair 104
Retriever - Labrador 12
Domestic Longhair 12
Domestic Mediumhair 11
Domestic (unspecified) 8
Cat (unknown) 7
Cat (other) 7
Bichon Frise 4
Retriever - Golden 4
Maine Coon 4

Associated Drugs

Spinosad 29
Frunevetmab 29
Methimazole 23
Trilostane 17
Imidacloprid + Moxidectin 12
Bexagliflozin 10
Cefovecin 9
Cyclosporine 9
Fluralaner Spot-On Solution 9
Levothyroxine 8
Selamectin 7
Maropitant Citrate 7
Oclacitinib Maleate 7
Fluralaner/Moxidectin Spot-On 7
Insulin Injectable Vial 6
Emodepside + Praziquantel 5
Meloxicam 5
Enrofloxacin 5
Recombinant Human Insulin 5
Nitenpyram 5

Hyperthyroidism Reaction Insights

239 reports name Hyperthyroidism; 34 recorded a death outcome (14.2% of reported events, not a population-level mortality rate). VeDDRA code: 403.

By species: Cat (165 reports), Dog (72 reports), Human (2 reports). By breed: Domestic Shorthair (104), Retriever - Labrador (12), Domestic Longhair (12).

Most co-reported drugs: Spinosad (29 reports), Frunevetmab (29 reports), Methimazole (23 reports), Trilostane (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.