Reaction profile

The FDA adverse-event record for bloody foam in mouth and nose

53 FDA reports name bloody foam in mouth and nose, a lower-volume reaction in the CVM extract (VeDDRA 2537). Plate stamps and neighbourhood peers follow.

#1703 of 2,481
by report volume (all reactions)
53
reports citing this reaction
84.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bloody foam in mouth and nose has 53 reports now versus 52 in that prior snapshot: 1 more (1.9%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bloody foam in mouth and nose changes

FDA AER · VeDDRA plate

Code 2537 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 53 reports
  • DEATH-HOT 84.9%
  • MID-PACK #1703/2481
  • PHOTO-FINISH Decreased skin turgor
  • SPECIES-DOG Dog · 23
  • DRUG-LEAD Polysulfated Glyc… · 4
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Decreased skin turgor (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Bloody foam in mouth and nose

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Bloody foam in mouth… · this…53Decreased skin turgor · near53Easily startled · near53Footpad disorder NOS · near53IGA Animal morbidity… · near53Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Bloody foam in mouth and nose

Bloody foam in mouth and nose: high death-coded share in the FDA AER plate

Signature read: Bloody foam in mouth and nose's 84.9% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 53 named reports in the openFDA extract. Death-coded share is upper-third: 45 of 53 reports (84.9% of named reports). Nearest volume peer: Decreased skin turgor (±0 reports). Lead species Dog (23). Lead co-reported drug Polysulfated Glycosaminoglycan (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 23
Cattle 17
Cat 11
Horse 2

Breeds Most Affected

Domestic Shorthair 8
Aberdeen Angus 5
Mixed (Cattle) 3
Retriever - Labrador 3
Holstein-Friesian also known as Holstein 2
Domestic Mediumhair 2
Cattle (other) 2
Rottweiler 2
Dog (unknown) 2
Schnauzer - Miniature 2

Associated Drugs

Polysulfated Glycosaminoglycan 4
Grapiprant 4
Famotidine 4
Maropitant Citrate 4
Cefovecin 4
Clostr Perf*2/Clos Others*4 Kb 3
Vit E/ Selenite Inj Solution 3
Imidacloprid + Moxidectin 2
Tildipirosin Injectable 2
Meloxicam 2
Isoflurane 2
Intranasal Bordetella Vaccine 2
Fluralaner Chew Tablets 2
Dexmedetomidine Hydrochloride 2
Butorphanol 2
Doramectin 2
Clostridium Novyi, 8296;Clostridium Perfringens Type C, Pc8 2
Moxidectin 2
Milbemycin Oxime 2
Mirtazapine 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Bloody foam in mouth and nose, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (84.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bloody foam in mouth and nose (#1703 of 2,481 by report volume); death-coded 84.9%. PlainBreed reaction plate · death-coded share stamp 84.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →