Reaction profile

The FDA adverse-event record for bloody foam in mouth and nose

52 FDA adverse-event reports reference bloody foam in mouth and nose (VeDDRA 2537). See the species, breeds, and drugs most associated with it below.

52
reports citing this reaction
86.5%
death-coded share
Dog
most-affected species
Grapiprant
most-associated drug
Verify with FDA CVM →
52
Total Reports
45
Deaths
86.5%
Death Rate

Species Most Affected

Dog 22
Cattle 17
Cat 11
Horse 2

Breeds Most Affected

Domestic Shorthair 8
Aberdeen Angus 5
Mixed (Cattle) 3
Retriever - Labrador 3
Holstein-Friesian also known as Holstein 2
Domestic Mediumhair 2
Rottweiler 2
Cattle (other) 2
Dog (unknown) 2
Schnauzer - Miniature 2

Associated Drugs

Grapiprant 4
Polysulfated Glycosaminoglycan 4
Famotidine 4
Maropitant Citrate 4
Cefovecin 4
Vit E/ Selenite Inj Solution 3
Clostr Perf*2/Clos Others*4 Kb 3
Imidacloprid + Moxidectin 2
Meloxicam 2
Isoflurane 2
Intranasal Bordetella Vaccine 2
Tildipirosin Injectable 2
Fluralaner Chew Tablets 2
Dexmedetomidine Hydrochloride 2
Butorphanol 2
Doramectin 2
Clostridium Novyi, 8296;Clostridium Perfringens Type C, Pc8 2
Moxidectin 2
Milbemycin Oxime 2
Mirtazapine 2

Bloody foam in mouth and nose Reaction Insights

52 reports name Bloody foam in mouth and nose; 45 recorded a death outcome (86.5% of reported events, not a population-level mortality rate). VeDDRA code: 2537.

By species: Dog (22 reports), Cattle (17 reports), Cat (11 reports). By breed: Domestic Shorthair (8), Aberdeen Angus (5), Mixed (Cattle) (3).

Most co-reported drugs: Grapiprant (4 reports), Polysulfated Glycosaminoglycan (4 reports), Famotidine (4 reports), Maropitant Citrate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.